Conventional / global / constitutive KO
●2 Models Available
Tigit Conditional Knockout, Knockout mouse models
Browse 2 Tigit mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tigit conditional knockout mouse, Tigit knockout mouse. Request a quote within 24 hours.
Why model Tigit
Tigit is the mouse ortholog of human TIGIT and encodes a single IgV domain inhibitory receptor bearing an ITIM and an ITT-like motif that is induced on activated and exhausted CD8 T cells, follicular helper cells, regulatory T cells, and NK cells, where it binds CD155 (Pvr) with high affinity and CD112 (Pvrl2) more weakly. Because CD226 engages the same ligands as a costimulatory receptor, TIGIT acts partly by outcompeting CD226 and disrupting its homodimerization, while cis interactions and Treg-intrinsic signaling shape ligand availability and IL-10 output. Design consequences are concrete: germline or conditional nulls test cell-intrinsic inhibition, ITIM or ITT-like knockins separate signaling from ligand sequestration, and ectodomain humanization is required whenever a clinical antibody with defined Fc effector function is evaluated, since Fc-dependent Treg depletion is a leading proposed mechanism. Cd96 and Cd226 modulate the same axis, so plan compound alleles with tumor control or Pdcd1 combination endpoints.
What Tigit mouse models are available?
ingenious targeting laboratory offers 2 distinct Tigit (TIGIT) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tigit model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tigit allele types
Knockout, conditional, knockin, humanized, and related paths for Tigit (human TIGIT). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Tigit mouse model?
We have 2 Tigit models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tigit Mouse Model Types
A Tigit knockout mouse has the Tigit gene permanently inactivated, enabling loss of function studies. A Tigit conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tigit, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tigit organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Tigit.