Conventional / global / constitutive KO
●2 Models Available
Timp1 Conditional Knockout, Knockout mouse models
Browse 2 Timp1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Timp1 conditional knockout mouse, Timp1 knockout mouse. Contact us for availability and fast turnaround.
Why model Timp1
Timp1, the mouse ortholog of human TIMP1, encodes tissue inhibitor of metalloproteinases 1, a glycoprotein whose N-terminal domain inserts a Cys1-containing wedge into the MMP active site so that the alpha amino group and carbonyl chelate the catalytic zinc, giving broad inhibition of soluble MMPs including MMP1, MMP3, and MMP9 but notably weak activity against MT1-MMP (Mmp14). Independently of protease inhibition, TIMP1 signals as a cytokine through CD63 and integrin beta 1, activating FAK, PI3K, and ERK to promote survival, and it shapes hepatic stellate cell and neutrophil behavior during fibrosis and metastatic niche formation. Nulls are viable, so germline deletion works, while conditional alleles resolve stromal versus hepatic sources and Cys1 or CD63-binding knockins separate inhibitory from signaling functions, an essential control given the dual activity. Timp2, Timp3, and Timp4 overlap on shared targets, so consider compound genetics and follow fibrosis, metastasis, or gelatinase endpoints.
What Timp1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Timp1 (TIMP1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Timp1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Timp1 allele types
Knockout, conditional, knockin, humanized, and related paths for Timp1 (human TIMP1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Timp1 catalog models
2 Timp1 lines with QC documentation and technical support. Timp1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Timp1 mouse model?
We have 2 Timp1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Timp1 Mouse Model Types
A Timp1 knockout mouse has the Timp1 gene permanently inactivated, enabling loss of function studies. A Timp1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Timp1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Timp1 organized by modification type. Each URL is indexable and matches common search patterns.