Conventional / global / constitutive KO
●1 Model Available
Timp4 Conditional Knockout mouse model
Browse 1 Timp4 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Timp4
Timp4, the mouse ortholog of human TIMP4, encodes the most restricted family member, expressed predominantly in heart, brain, adipose tissue, and platelets, where its N-terminal Cys1 wedge chelates the catalytic zinc of MMP1, MMP2, MMP7, MMP9, and MT1-MMP, and its C-terminal domain binds pro-MMP2 in a manner analogous to but weaker than TIMP2. Platelet-derived TIMP4 modulates aggregation and local matrix remodeling at sites of injury, and cardiac TIMP4 loss shifts the protease inhibitor balance during pressure overload and infarction, linking the gene to adverse remodeling rather than to developmental patterning. Nulls are viable and fertile with essentially normal baseline morphology, so germline deletion is a low-risk starting point but usually needs a stress challenge to reveal phenotype, while conditional alleles resolve cardiomyocyte versus fibroblast contributions and domain knockins separate inhibition from pro-MMP2 binding. Given clear redundancy with Timp1, Timp2, and Timp3, plan compound genetics around remodeling, infarct expansion, or adipose fibrosis endpoints.
What Timp4 mouse models are available?
ingenious targeting laboratory offers 1 distinct Timp4 (TIMP4) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Timp4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Timp4 allele types
Knockout, conditional, knockin, humanized, and related paths for Timp4 (human TIMP4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Timp4 catalog models
1 Timp4 line with QC documentation and technical support. Timp4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Timp4-Flox
Conditional KnockoutKO/CKO mice
liveCKO 251954
Looking for a Timp4 mouse model?
We have 1 Timp4 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Timp4 Mouse Model Types
A Timp4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Timp4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Timp4 organized by modification type. Each URL is indexable and matches common search patterns.