Conventional / global / constitutive KO
●2 Models Available
Traf5 Conditional Knockout, Knockout mouse models
Browse 2 Traf5 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Traf5 conditional knockout mouse, Traf5 knockout mouse. Contact us for availability and fast turnaround.
Why model Traf5
Traf5, the mouse ortholog of human TRAF5, encodes the closest structural relative of TRAF2, sharing a RING domain, zinc fingers, and a trimerizing TRAF domain, and it is recruited to CD27, CD30, CD40, lymphotoxin beta receptor, and TNFR2 to support NF-kB and JNK activation, in some assays acting interchangeably with TRAF2 while in others tuning IL-6 driven STAT3 signaling and helper T cell differentiation. Because its contribution is largely additive rather than unique, germline nulls are viable and fertile with only subtle defects in CD27 and CD40 driven responses, which is precisely the redundancy trap to plan for: a single Traf5 knockout will usually not report pathway dependence, and compound Traf2 Traf5 conditional genetics is required to expose shared function. RING-dead knockins separate ligase activity from scaffolding within otherwise intact receptor complexes. Fit the allele set to T cell dependent antibody responses, non-canonical NF-kB activity, or airway inflammation endpoints.
What Traf5 mouse models are available?
ingenious targeting laboratory offers 2 distinct Traf5 (TRAF5) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Traf5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Traf5 allele types
Knockout, conditional, knockin, humanized, and related paths for Traf5 (human TRAF5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Traf5 catalog models
2 Traf5 lines with QC documentation and technical support. Traf5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Traf5 mouse model?
We have 2 Traf5 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Traf5 Mouse Model Types
A Traf5 knockout mouse has the Traf5 gene permanently inactivated, enabling loss of function studies. A Traf5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Traf5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Traf5 organized by modification type. Each URL is indexable and matches common search patterns.