Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · SPERM
Acvr2b Conditional Knockout, Humanized, Knockout mouse models
Browse 3 Acvr2b mouse models including conditional knockout, humanized, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Acvr2b conditional knockout mouse, Acvr2b humanized mouse, Acvr2b knockout mouse. Request a quote within 24 hours.
Why model Acvr2b
Acvr2b, mouse ortholog of human ACVR2B, encodes the type IIB activin receptor, the highest affinity receptor for myostatin and GDF11 and a principal node controlling skeletal muscle mass, axial patterning and left-right asymmetry. Ligand capture drives constitutive kinase activity that phosphorylates ALK4 or ALK5, mobilizing SMAD2 and SMAD3, and dominant negative or Fc soluble ectodomain versions produce profound muscle hypertrophy, which is why this receptor anchors so much cachexia and muscular dystrophy pharmacology. Null animals die perinatally with cardiac and situs defects, so conditional deletion is required for adult muscle and metabolic questions, while ectodomain humanization gives an honest platform for testing bimagrumab class antibodies and engineered ligand traps against the human binding interface. Acvr2a shares ligands and compensates substantially, so interpret single-locus data cautiously. Choose conditional null alleles for lineage requirement, kinase-dead knockins for signaling dissection, and humanized ectodomains for biologic engagement, always with a validated tissue-restricted Cre.
What Acvr2b mouse models are available?
ingenious targeting laboratory offers 3 distinct Acvr2b (ACVR2B) catalog mouse models, featuring conditional knockout, standard knockout, and humanized. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Acvr2b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Acvr2b allele types
Knockout, conditional, knockin, humanized, and related paths for Acvr2b (human ACVR2B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Acvr2b catalog models
3 Acvr2b lines with QC documentation and technical support. Acvr2b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout. Acvr2b humanized models carry the human gene sequence for translational research.
- Order
Acvr2b-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-4 of Acvr2b gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Acvr2b gene.
Sperm CryopreservedCKO 2100346 - Order
hACVR2B
HUTarget-Humanized
The endogenous mouse Acvr2b gene was replaced by human ACVR2B gene.
LiveHU 252267 - Order
Acvr2b-KO
KOKO
exon 2-4 of Acvr2b gene was deleted to generate Acvr2b knockout mice.
Sperm CryopreservedKO 226319
Looking for a Acvr2b mouse model?
We have 3 Acvr2b models in stock — including Conditional Knockout, Humanized, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Acvr2b Mouse Model Types
A Acvr2b knockout mouse has the Acvr2b gene permanently inactivated, enabling loss of function studies. A Acvr2b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Acvr2b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. A Acvr2b humanized mouse replaces the mouse Acvr2b gene with the human ortholog for translational research and drug development.
Modifications available
Jump to catalog backed pages for Acvr2b organized by modification type. Each URL is indexable and matches common search patterns.
Acvr2b mouse model FAQ
What Acvr2b Conditional Knockout mouse models are available?
When Acvr2b Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Acvr2b knockout embryonic lethal in mice?
It depends on background and allele design. Some Acvr2b germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Acvr2b animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Acvr2b?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Acvr2b line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.