Conventional / global / constitutive KO
●2 Models Available
Aldh1a1 Conditional Knockout, Knockout mouse models
Browse 2 Aldh1a1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Aldh1a1 conditional knockout mouse, Aldh1a1 knockout mouse. Contact us for availability and fast turnaround.
Why model Aldh1a1
Aldh1a1, the mouse ortholog of human ALDH1A1, encodes the cytosolic NAD+-dependent retinaldehyde dehydrogenase RALDH1, which performs the irreversible oxidation of retinaldehyde to all-trans retinoic acid and thereby supplies ligand to nuclear RAR and RXR heterodimers in dorsal retina, liver, lung, and visceral adipose tissue. The same tetrameric active site detoxifies reactive lipid aldehydes such as 4-hydroxynonenal and metabolizes oxazaphosphorine chemotherapeutics, which is why high enzyme activity defines ALDEFLUOR-positive tumor populations and cyclophosphamide resistance. Since germline nulls are viable and fertile, constitutive deletion suits metabolic and adipose questions, whereas conditional floxed alleles isolate autonomous requirements in retina or tumor compartments, and catalytically dead point knockins separate enzymatic output from noncatalytic roles. Be aware that Aldh1a2, Aldh1a3, and Aldh8a1 generate retinoic acid in overlapping domains, so single-locus loss is often buffered. Humanized knockins are the correct substrate for isoform-selective inhibitor pharmacology, while compound Raldh genetics is required to collapse local retinoid signaling outright.
What Aldh1a1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Aldh1a1 (ALDH1A1) catalog mouse models in the Retinoic acid axis family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Aldh1a1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
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Aldh1a1 allele types
Knockout, conditional, knockin, humanized, and related paths for Aldh1a1 (human ALDH1A1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Aldh1a1 catalog models
2 Aldh1a1 lines with QC documentation and technical support. Aldh1a1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Aldh1a1 mouse model?
We have 2 Aldh1a1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Aldh1a1 Mouse Model Types
A Aldh1a1 knockout mouse has the Aldh1a1 gene permanently inactivated, enabling loss of function studies. A Aldh1a1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Aldh1a1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Aldh1a1 organized by modification type. Each URL is indexable and matches common search patterns.