Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · IN PRODUCTION
Aldh1a2 Conditional Knockout, Knockout mouse models
Browse 2 Aldh1a2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Aldh1a2 conditional knockout mouse, Aldh1a2 knockout mouse. Request a quote within 24 hours.
Why model Aldh1a2
Encoding RALDH2, Aldh1a2 is the mouse ortholog of human ALDH1A2 and the dominant source of embryonic all-trans retinoic acid, oxidizing retinaldehyde within paraxial and lateral plate mesoderm, epicardium, and meninges to establish the posterior-to-anterior retinoid gradient read by RAR and Hox targets. Loss of this single enzyme is not tolerated: germline nulls arrest around midgestation with unlooped heart tubes, absent forelimb buds, shortened trunks, and disrupted hindbrain segmentation, a lethality partially rescuable by maternal retinoic acid supplementation, so timed dietary rescue must be planned into any constitutive line. That embryonic requirement makes conditional floxed alleles the practical design for adult immunology, where dendritic cell and stromal RALDH2 drives gut homing and regulatory T cell induction. Paralogous Aldh1a1 and Aldh1a3 occupy largely nonoverlapping domains and do not rescue the early mesodermal deficit. Pair the flox with tissue-restricted Cre drivers such as Cd11c-Cre or Wt1-Cre when the endpoint is retinoid-dependent cell fate rather than gross morphogenesis.
What Aldh1a2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Aldh1a2 (RALDH2) catalog mouse models in the Retinoic acid axis family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Aldh1a2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Aldh1a2 allele types
Knockout, conditional, knockin, humanized, and related paths for Aldh1a2 (human ALDH1A2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Aldh1a2 catalog models
2 Aldh1a2 lines with QC documentation and technical support. Aldh1a2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Aldh1a2-Flox(2)
CKOCKO
These mice carry loxP sites flanking exon 2-4 of Aldh1a2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Aldh1a2 gene.
In production — inquireCKO 252522 - Order
Aldh1a2-KO
KOKO
The exon 2-4 of Aldh1a2 gene was deleted to generate Aldh1a2 knockout mouse.
LiveKO 260298
Looking for a Aldh1a2 mouse model?
We have 2 Aldh1a2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Aldh1a2 Mouse Model Types
A Aldh1a2 knockout mouse has the Aldh1a2 gene permanently inactivated, enabling loss of function studies. A Aldh1a2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Aldh1a2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Aldh1a2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Aldh1a2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.