Conventional / global / constitutive KO
●1 Model Available
Aldh1a2 Conditional Knockout mouse model
Browse 1 Aldh1a2 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Aldh1a2
Encoding RALDH2, Aldh1a2 is the mouse ortholog of human ALDH1A2 and the dominant source of embryonic all-trans retinoic acid, oxidizing retinaldehyde within paraxial and lateral plate mesoderm, epicardium, and meninges to establish the posterior-to-anterior retinoid gradient read by RAR and Hox targets. Loss of this single enzyme is not tolerated: germline nulls arrest around midgestation with unlooped heart tubes, absent forelimb buds, shortened trunks, and disrupted hindbrain segmentation, a lethality partially rescuable by maternal retinoic acid supplementation, so timed dietary rescue must be planned into any constitutive line. That embryonic requirement makes conditional floxed alleles the practical design for adult immunology, where dendritic cell and stromal RALDH2 drives gut homing and regulatory T cell induction. Paralogous Aldh1a1 and Aldh1a3 occupy largely nonoverlapping domains and do not rescue the early mesodermal deficit. Pair the flox with tissue-restricted Cre drivers such as Cd11c-Cre or Wt1-Cre when the endpoint is retinoid-dependent cell fate rather than gross morphogenesis.
What Aldh1a2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Aldh1a2 (RALDH2) catalog mouse model in the Retinoic acid axis family, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Aldh1a2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
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Aldh1a2 allele types
Knockout, conditional, knockin, humanized, and related paths for Aldh1a2 (human ALDH1A2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Aldh1a2 catalog models
1 Aldh1a2 line with QC documentation and technical support. Aldh1a2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Aldh1a2-Flox(2)
Conditional KnockoutKO/CKO mice
In production — inquireCKO 252522
Looking for a Aldh1a2 mouse model?
We have 1 Aldh1a2 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Aldh1a2 Mouse Model Types
A Aldh1a2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Aldh1a2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Aldh1a2 organized by modification type. Each URL is indexable and matches common search patterns.