What Apc Conditional Knockout mouse models are available?

When Apc Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Apc knockout embryonic lethal in mice?

It depends on background and allele design. Some Apc germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Apc animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Apc?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●8 Models Available

Apc Conditional Knockout, Knockin, Knockout mouse models

Browse 8 Apc mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Apc conditional knockout mouse, Apc knockin mouse, Apc knockout mouse, Apc xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Apc

Apc, the mouse ortholog of human APC, encodes the large scaffold that nucleates the beta-catenin destruction complex, using 15 amino acid and 20 amino acid repeats to bind beta-catenin and SAMP repeats to bind AXIN1 and AXIN2, thereby positioning CK1 alpha and GSK3 beta for the priming and processive phosphorylations that create the beta-TrCP degron. Independently, the armadillo repeat region and C-terminal EB1 and DLG binding sites control microtubule plus end dynamics and mitotic spindle fidelity, so truncating alleles produce both Wnt hyperactivation and chromosomal instability. Mutation position matters enormously: the mutation cluster region retains some repeats and yields intermediate signaling, which is why allelic series such as Min, 1638N and 1322T give different tumor multiplicities. Homozygous null is embryonic lethal, mandating floxed exon 14 or 15 designs with tissue-restricted Cre for intestinal, hepatic or mammary work. Match truncation position to the desired Wnt setpoint rather than assuming all Apc alleles are equivalent.

What Apc mouse models are available?

ingenious targeting laboratory offers 8 distinct Apc (APC) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
8 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Apc model types

PathAvailability

Knockout
View catalog
Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Apc allele types

Knockout, conditional, knockin, humanized, and related paths for Apc (human APC). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

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Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Apc catalog models

8 Apc lines with QC documentation and technical support. Apc floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Apc-Flox
Conditional Knockout
KO/CKO mice, disease model mice
liveCKO 200013
Order
Apc-L850X
Knockin
point mutantion mice, disease model mice
liveKI 200001
Order
Apc-A1323*
Knockin
point mutantion mice
sperm cryopreservationKI 234116
Order
Apc-KO
Knockout
KO/CKO mice, disease model mice
embryo cryopreservationKO 200612
Order
Apc-KO(2)
Knockout
KO/CKO mice
In production — inquireKO 252883
Order
Apc-Flox/Kras-LSL-G12D/Vil1-CreERT2
Xenograft-Applicable
KO/CKO mice,point mutantion mice,Cre/Dre Toolbox of Mice, disease model mice
embryo cryopreservationXA 234925
Order
Apc-Flox/Kras-LSL-G12D
Xenograft-Applicable
KO/CKO mice,point mutantion mice
embryo cryopreservationXA 234924
Order
Apc-Flox/Trp53-Flox/Kras-LSL-G12D
Xenograft-Applicable
KO/CKO mice,point mutantion mice
liveXA 242192
Order

Looking for a Apc mouse model?

We have 8 Apc models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Apc Mouse Model Types

A Apc knockout mouse has the Apc gene permanently inactivated, enabling loss of function studies. A Apc conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Apc, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Apc knockin models carry a precisely inserted sequence at the Apc locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Apc organized by modification type. Each URL is indexable and matches common search patterns.

Apc Conditional Knockout Apc Knockin Apc Knockout Apc Xenograft-Applicable Apc cDNA Knockin Apc Epitope Tag Knockin Apc Humanized Apc Inducible Knockout Apc Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Apc.

intestinal Apc conditional knockout

Related Gene Targets

Apcdd1 ApcMin Apcs