Conventional / global / constitutive KO
●8 Models Available
READY TO SHIP!
LIVE · SPERM · EMBRYO · IN PRODUCTION
Apc Conditional Knockout, Knockin, Knockout mouse models
Browse 8 Apc mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Apc conditional knockout mouse, Apc knockin mouse, Apc knockout mouse, Apc xenograft-applicable mouse. Request a quote within 24 hours.
Why model Apc
Apc, the mouse ortholog of human APC, encodes the large scaffold that nucleates the beta-catenin destruction complex, using 15 amino acid and 20 amino acid repeats to bind beta-catenin and SAMP repeats to bind AXIN1 and AXIN2, thereby positioning CK1 alpha and GSK3 beta for the priming and processive phosphorylations that create the beta-TrCP degron. Independently, the armadillo repeat region and C-terminal EB1 and DLG binding sites control microtubule plus end dynamics and mitotic spindle fidelity, so truncating alleles produce both Wnt hyperactivation and chromosomal instability. Mutation position matters enormously: the mutation cluster region retains some repeats and yields intermediate signaling, which is why allelic series such as Min, 1638N and 1322T give different tumor multiplicities. Homozygous null is embryonic lethal, mandating floxed exon 14 or 15 designs with tissue-restricted Cre for intestinal, hepatic or mammary work. Match truncation position to the desired Wnt setpoint rather than assuming all Apc alleles are equivalent.
What Apc mouse models are available?
ingenious targeting laboratory offers 8 distinct Apc (APC) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 8 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Apc model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Apc allele types
Knockout, conditional, knockin, humanized, and related paths for Apc (human APC). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Apc catalog models
8 Apc lines with QC documentation and technical support. Apc floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Apc-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 15 of Apc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Apc gene.
LiveCKO 200013 - Order
Apc-A1323*
KIPoint Mutation
These strains carry a A1323* mutation of Apc gene.
Sperm CryopreservedKI 234116 - Order
Apc-L850X
KIPoint Mutation, Disease Model
Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)iTL(KI 200001) strain of iTL refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)iTL strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.
LiveKI 200001 - Order
Apc-KO(2)
KOKO
The exon 14 of Apc gene was deleted to generate Apc knockout mouse.
In production — inquireKO 252883 - Order
Apc-KO
KOKO, Disease Model
Exon 3 of APC gene was deleted to generate APC knockout mice.
Embryo CryopreservedKO 200612 - Order
Apc-Flox/Kras-LSL-G12D/Vil1-CreERT2
XAKO, Point Mutation, Cre/Dre Toolbox, Disease Model
The Apc-Flox/Kras-LSL-G12D(XA 234924) was crossed with Vil1-CreERT2(KI 225020) to generate Apc-Flox/Kras-LSL-G12D/Vil1-CreERT2 mice.
Embryo CryopreservedXA 234925 - Order
Apc-Flox/Trp53-Flox/Kras-LSL-G12D
XAKO, Point Mutation
The Apc-Flox(CKO 200013) was crossed with Trp53-Flox/Kras-LSL-G12D(CKO 233079) to generate Apc-Flox/Trp53-Flox/Kras-LSL-G12D mice.
LiveXA 242192 - Order
Apc-Flox/Kras-LSL-G12D
XAKO, Point Mutation
The Apc-Flox(CKO 200013) was crossed with Kras-LSL-G12D(KI 190003) to generate Apc-Flox/Kras-LSL-G12D mice.
Embryo CryopreservedXA 234924
Looking for a Apc mouse model?
We have 8 Apc models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model8
Models Available
4
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Apc Mouse Model Types
A Apc knockout mouse has the Apc gene permanently inactivated, enabling loss of function studies. A Apc conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Apc, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Apc knockin models carry a precisely inserted sequence at the Apc locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Apc organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Apc.
Breed this line with ingenious targeting laboratory
Send the Apc line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.