Conventional / global / constitutive KO
●1 Model Available
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Cacnb4 Conditional Knockout mouse model
Browse 1 Cacnb4 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Cacnb4
CaVβ4, encoded by Cacnb4 as the ortholog of human CACNB4, is the cerebellum-enriched β subunit that partners CaV2.1 at parallel and climbing fiber terminals, engaging the α-interaction domain through its guanylate kinase domain to control surface expression and inactivation kinetics; a short nuclear isoform additionally binds chromatin regulators and the phosphatase regulatory subunit B56δ, giving the gene a transcriptional arm independent of conductance. The spontaneous lethargic allele, a splice mutation that abolishes α1 binding, causes ataxia, absence-like spike-wave discharges and lymphocyte defects, and human variants segregate with juvenile myoclonic epilepsy and episodic ataxia. Because homozygous loss produces severe ataxia and seizures with poor postweaning survival, a conditional null crossed to Pcp2-Cre or a granule cell driver is the practical route to adult cerebellar physiology, while a patient missense knockin separates trafficking from nuclear signaling. Cacnb1, Cacnb2 and Cacnb3 partially substitute, so quantify β subunit stoichiometry directly.
What Cacnb4 mouse models are available?
ingenious targeting laboratory offers 1 distinct Cacnb4 (CACNB4) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cacnb4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cacnb4 allele types
Knockout, conditional, knockin, humanized, and related paths for Cacnb4 (human CACNB4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cacnb4 catalog models
1 Cacnb4 line with QC documentation and technical support. Cacnb4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Cacnb4-Flox
CKOCKO
These mice carry loxP sites flanking exon4 of Cacnb4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cacnb4 gene.
In DevelopmentCKO 261097
Looking for a Cacnb4 mouse model?
We have 1 Cacnb4 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cacnb4 Mouse Model Types
A Cacnb4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cacnb4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cacnb4 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Cacnb4 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.