Conventional / global / constitutive KO
●4 Models Available
Cd274 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Cd274 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cd274 conditional knockout mouse, Cd274 knockin mouse, Cd274 knockout mouse. Request a quote within 24 hours.
Why model Cd274
Cd274 encodes PD-L1 (B7-H1), the mouse ortholog of human CD274, a type I membrane protein with IgV and IgC2 domains whose IgV face engages PD-1 (Pdcd1) to recruit SHP-2 to the PD-1 ITSM, dephosphorylating CD28 and proximal TCR components and thereby raising the activation threshold of effector T cells. Surface abundance is controlled transcriptionally by IFN-gamma through JAK and STAT1 to IRF1, by MYC and NF-kappaB, by structural variants of the 3 prime untranslated region, and post-translationally by CMTM6 mediated recycling versus glycosylation-dependent degradation; PD-L1 also binds CD80 in cis and exists in exosomal and soluble forms. Nulls are viable but show exaggerated T cell responses and autoimmune susceptibility. Because atezolizumab and durvalumab do not cross-react, epitope-matched humanization is the decisive allele for checkpoint pharmacology and biomarker work, whereas conditional deletion with tumor cell, dendritic cell, or endothelial Cre resolves which compartment enforces suppression.
What Cd274 mouse models are available?
ingenious targeting laboratory offers 4 distinct Cd274 (PD-L1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cd274 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cd274 allele types
Knockout, conditional, knockin, humanized, and related paths for Cd274 (human CD274). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cd274 catalog models
4 Cd274 lines with QC documentation and technical support. Cd274 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cd274 mouse model?
We have 4 Cd274 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cd274 Mouse Model Types
A Cd274 knockout mouse has the Cd274 gene permanently inactivated, enabling loss of function studies. A Cd274 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cd274, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cd274 knockin models carry a precisely inserted sequence at the Cd274 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Cd274 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Cd274.