Gdf10 Knockout mouse models
Gdf10, mouse ortholog of human GDF10 and also designated BMP3B, encodes a TGF-beta superfamily ligand that, like its closest paralog BMP3, signals through activin-type receptors ACVR2B with ALK4 to phosphorylate SMAD2 and SMAD3 rather than the SMAD1, SMAD5, and SMAD8 branch, positioning it as a counterweight to osteogenic BMP output in bone and as a TGF-beta-like input elsewhere. Expression is high in cerebellar Purkinje neurons, and after cortical stroke it is induced in peri-infarct layer 5 neurons, where it drives axonal sprouting and functional recovery by modulating PTEN, mTOR, and growth-associated transcriptional programs, making it a plasticity effector rather than a developmental patterning ligand. Nulls are viable with subtle skeletal and neurological phenotypes, so constitutive deletion is workable, while conditional floxed alleles with Pcp2-Cre or Rbp4-Cre attribute recovery effects to specific neuron classes and overexpression or AAV delivery tests therapeutic sprouting. Given overlap with Bmp3 in SMAD2 and SMAD3 signaling, compound alleles clarify bone mass endpoints.
Gdf10 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Gdf10 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Gdf10 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Gdf10-KO | Knockout | KO/CKO mice | In production — inquire | KO 252927 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Gdf10 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Gdf10 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Gdf10 Knockout mouse models are available?
When Gdf10 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Gdf10 knockout embryonic lethal in mice?
It depends on background and allele design. Some Gdf10 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Gdf10 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Gdf10?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.