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Gdf6 Knockout mouse models
Gdf6 is the mouse ortholog of human GDF6 and encodes BMP13, a ligand that signals through ALK3 and ALK6 with BMPR2 to activate SMAD1, SMAD5, and SMAD8, and that heterodimerizes with GDF5 to alter receptor preference and antagonist sensitivity. Its dominant requirement is ocular morphogenesis, where dosage controls optic fissure closure and retinal specification, explaining human microphthalmia with coloboma, Leber congenital amaurosis, and Klippel-Feil presentations, alongside segment-specific roles in wrist, ankle, and vertebral joint formation. Since nulls survive with restricted joint fusions and variable eye defects, conditional deletion is most useful for separating optic vesicle from periocular mesenchyme requirements, patient missense knockins test whether variants are hypomorphic or dominant negative through heterodimer poisoning, and humanization enables ligand trap and antibody pharmacology. Because Gdf5 and Gdf7 buffer overlapping skeletal domains, design compound conditional genetics early rather than reading a single-locus knockout as definitive.
Global Gdf6 deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Gdf6 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Gdf6 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Gdf6-KO | KO | KO | DEVELOPING | KO 263123 | Inquire |
| The exon 2 of Gdf6 gene was deleted to generate Gdf6 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Gdf6 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Gdf6 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Gdf6 Knockout mouse models are available?
When Gdf6 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Gdf6 knockout embryonic lethal in mice?
It depends on background and allele design. Some Gdf6 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Gdf6 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Gdf6?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Gdf6 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.