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Gdf5 Knockout mouse models
Known biochemically as cartilage-derived morphogenetic protein 1, Gdf5 is the mouse ortholog of human GDF5 and produces a BMP-family ligand with unusual selectivity for BMPR1B (ALK6) over ALK3, which it uses with BMPR2 or ActRIIA to drive SMAD1, SMAD5, and SMAD8 phosphorylation in the joint interzone, articular surface, tendon, and ligament. The spontaneous brachypodism allele is a Gdf5 null that shortens limb segments and eliminates specific joints, and human mutations span brachydactyly type C, Grebe and Hunter-Thompson chondrodysplasia, and gain-of-function symphalangism, with the common regulatory variant rs143383 in the R2 and R3 elements conferring osteoarthritis risk. Nulls are viable, so allele choice follows the question: conditional deletion for adult articular maintenance, coding knockins for chondrodysplasia mechanism, and enhancer knockins for the human osteoarthritis risk haplotype. Gdf6 and Gdf7 overlap in joint and tendon programs, so compound alleles and a joint-restricted Gdf5-Cre driver sharpen skeletal endpoints considerably.
Gdf5 null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Gdf5 Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Gdf5 knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Gdf5-KO | KO | KO | DEVELOPING | KO 260207 | Inquire |
| The exon 1 of Gdf5 gene was deleted to generate Gdf5 knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Gdf5 Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Gdf5 allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Gdf5 Knockout mouse models are available?
When Gdf5 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Gdf5 knockout embryonic lethal in mice?
It depends on background and allele design. Some Gdf5 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Gdf5 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Gdf5?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the Gdf5 Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.