Conventional / global / constitutive KO
●2 Models Available
Gdf10 Conditional Knockout, Knockout mouse models
Browse 2 Gdf10 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gdf10 conditional knockout mouse, Gdf10 knockout mouse. Request a quote within 24 hours.
Why model Gdf10
Gdf10, mouse ortholog of human GDF10 and also designated BMP3B, encodes a TGF-beta superfamily ligand that, like its closest paralog BMP3, signals through activin-type receptors ACVR2B with ALK4 to phosphorylate SMAD2 and SMAD3 rather than the SMAD1, SMAD5, and SMAD8 branch, positioning it as a counterweight to osteogenic BMP output in bone and as a TGF-beta-like input elsewhere. Expression is high in cerebellar Purkinje neurons, and after cortical stroke it is induced in peri-infarct layer 5 neurons, where it drives axonal sprouting and functional recovery by modulating PTEN, mTOR, and growth-associated transcriptional programs, making it a plasticity effector rather than a developmental patterning ligand. Nulls are viable with subtle skeletal and neurological phenotypes, so constitutive deletion is workable, while conditional floxed alleles with Pcp2-Cre or Rbp4-Cre attribute recovery effects to specific neuron classes and overexpression or AAV delivery tests therapeutic sprouting. Given overlap with Bmp3 in SMAD2 and SMAD3 signaling, compound alleles clarify bone mass endpoints.
What Gdf10 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gdf10 (GDF10) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gdf10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gdf10 allele types
Knockout, conditional, knockin, humanized, and related paths for Gdf10 (human GDF10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gdf10 catalog models
2 Gdf10 lines with QC documentation and technical support. Gdf10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gdf10 mouse model?
We have 2 Gdf10 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gdf10 Mouse Model Types
A Gdf10 knockout mouse has the Gdf10 gene permanently inactivated, enabling loss of function studies. A Gdf10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gdf10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gdf10 organized by modification type. Each URL is indexable and matches common search patterns.