What Gdf5 Knockin mouse models are available?

When Gdf5 Knockin lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Gdf5 knockout embryonic lethal in mice?

It depends on background and allele design. Some Gdf5 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Gdf5 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Gdf5?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●1 Model Available

Gdf5 Knockin mouse model

Name: Gdf5-Cre
Brand: ingenious targeting laboratory
SKU: KI 240955
Availability: PreOrder

Browse 1 Gdf5 mouse model including knockin variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.

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Why model Gdf5

Known biochemically as cartilage-derived morphogenetic protein 1, Gdf5 is the mouse ortholog of human GDF5 and produces a BMP-family ligand with unusual selectivity for BMPR1B (ALK6) over ALK3, which it uses with BMPR2 or ActRIIA to drive SMAD1, SMAD5, and SMAD8 phosphorylation in the joint interzone, articular surface, tendon, and ligament. The spontaneous brachypodism allele is a Gdf5 null that shortens limb segments and eliminates specific joints, and human mutations span brachydactyly type C, Grebe and Hunter-Thompson chondrodysplasia, and gain-of-function symphalangism, with the common regulatory variant rs143383 in the R2 and R3 elements conferring osteoarthritis risk. Nulls are viable, so allele choice follows the question: conditional deletion for adult articular maintenance, coding knockins for chondrodysplasia mechanism, and enhancer knockins for the human osteoarthritis risk haplotype. Gdf6 and Gdf7 overlap in joint and tendon programs, so compound alleles and a joint-restricted Gdf5-Cre driver sharpen skeletal endpoints considerably.

What Gdf5 mouse models are available?

ingenious targeting laboratory offers 1 distinct Gdf5 (GDF5) catalog mouse model in the BMP/GDF family, featuring knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
1 Ready Catalog Line	Conditional Knockout (cKO) on request	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO) on request	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

Gdf5 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
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Humanized
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Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Gdf5 allele types

Knockout, conditional, knockin, humanized, and related paths for Gdf5 (human GDF5). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

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Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Gdf5 catalog models

1 Gdf5 line with QC documentation and technical support.

Gdf5-Cre
Knockin
Cre/Dre Toolbox of Mice
sperm cryopreservationKI 240955
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Looking for a Gdf5 mouse model?

We have 1 Gdf5 model available — including Knockin types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation