Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
DEVELOPING · IN PRODUCTION
Gdf6 Conditional Knockout, Knockout mouse models
Browse 2 Gdf6 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gdf6 conditional knockout mouse, Gdf6 knockout mouse. Request a quote within 24 hours.
Why model Gdf6
Gdf6 is the mouse ortholog of human GDF6 and encodes BMP13, a ligand that signals through ALK3 and ALK6 with BMPR2 to activate SMAD1, SMAD5, and SMAD8, and that heterodimerizes with GDF5 to alter receptor preference and antagonist sensitivity. Its dominant requirement is ocular morphogenesis, where dosage controls optic fissure closure and retinal specification, explaining human microphthalmia with coloboma, Leber congenital amaurosis, and Klippel-Feil presentations, alongside segment-specific roles in wrist, ankle, and vertebral joint formation. Since nulls survive with restricted joint fusions and variable eye defects, conditional deletion is most useful for separating optic vesicle from periocular mesenchyme requirements, patient missense knockins test whether variants are hypomorphic or dominant negative through heterodimer poisoning, and humanization enables ligand trap and antibody pharmacology. Because Gdf5 and Gdf7 buffer overlapping skeletal domains, design compound conditional genetics early rather than reading a single-locus knockout as definitive.
What Gdf6 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gdf6 (GDF6) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gdf6 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gdf6 allele types
Knockout, conditional, knockin, humanized, and related paths for Gdf6 (human GDF6). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gdf6 catalog models
2 Gdf6 lines with QC documentation and technical support. Gdf6 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Gdf6-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Gdf6 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gdf6 gene.
In production — inquireCKO 254153 - Order
Gdf6-KO
KOKO
The exon 2 of Gdf6 gene was deleted to generate Gdf6 knockout mouse.
In DevelopmentKO 263123
Looking for a Gdf6 mouse model?
We have 2 Gdf6 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gdf6 Mouse Model Types
A Gdf6 knockout mouse has the Gdf6 gene permanently inactivated, enabling loss of function studies. A Gdf6 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gdf6, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gdf6 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Gdf6 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.