Conventional / global / constitutive KO
●3 Models Available
Gria3 Conditional Knockout, Knockout mouse models
Browse 3 Gria3 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gria3 conditional knockout mouse, Gria3 knockout mouse. Request a quote within 24 hours.
Why model Gria3
Gria3 is X-linked in both species and, as the ortholog of human GRIA3, encodes GluA3, an AMPA receptor subunit with a short cytoplasmic tail that supports constitutive, activity-independent receptor cycling through PICK1 and GRIP interactions, in contrast with the regulated insertion driven by GluA1. GluA3-containing receptors are abundant in hippocampus, cortex, and auditory brainstem, and their fast kinetics depend on flip and flop splicing plus TARP association. Human GRIA3 missense variants produce X-linked intellectual disability with both loss-of-function and gain-of-function gating changes, including slowed deactivation and shifted agonist potency, which is why patient-specific knockin alleles are usually more informative than deletion. Constitutive nulls are viable with subtle synaptic phenotypes, so conditional alleles are reserved for cell-type attribution rather than for bypassing lethality. Because Gria1 and Gria2 readily substitute in heteromers, score subunit-resolved currents and rectification, and use humanized alleles when testing modulators with species-divergent binding sites.
What Gria3 mouse models are available?
ingenious targeting laboratory offers 3 distinct Gria3 (GRIA3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gria3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gria3 allele types
Knockout, conditional, knockin, humanized, and related paths for Gria3 (human GRIA3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gria3 catalog models
3 Gria3 lines with QC documentation and technical support. Gria3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gria3 mouse model?
We have 3 Gria3 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gria3 Mouse Model Types
A Gria3 knockout mouse has the Gria3 gene permanently inactivated, enabling loss of function studies. A Gria3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gria3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gria3 organized by modification type. Each URL is indexable and matches common search patterns.