Conventional / global / constitutive KO
●2 Models Available
Grin2b Conditional Knockout, Knockout mouse models
Browse 2 Grin2b mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Grin2b conditional knockout mouse, Grin2b knockout mouse. Contact us for availability and fast turnaround.
Why model Grin2b
GluN2B, encoded by Grin2b, the mouse ortholog of human GRIN2B, is the dominant NMDA receptor GluN2 subunit in embryonic and early postnatal brain, generating currents with slow deactivation and high charge transfer, and it is uniquely blocked by ifenprodil and related amino-terminal domain antagonists. Its exceptionally long cytoplasmic tail binds CaMKII with high affinity and scaffolds PSD-95 and SynGAP, so GluN2B is not merely a pore component but a signaling hub for synaptic plasticity and spine maturation. Constitutive nulls die perinatally with failed suckling and absent hippocampal long-term depression, which mandates floxed alleles combined with CaMKIIa-Cre or Emx1-Cre for adult work. Human GRIN2B variants cause intellectual disability and epileptic encephalopathy through both reduced current and gating gain of function, favoring targeted knockins, while tail-swap alleles separate ion flux from CaMKII recruitment. GluN2A upregulation partially masks loss, so measure ifenprodil-sensitive current directly rather than inferring composition.
What Grin2b mouse models are available?
ingenious targeting laboratory offers 2 distinct Grin2b (GRIN2B) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Grin2b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Grin2b allele types
Knockout, conditional, knockin, humanized, and related paths for Grin2b (human GRIN2B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Grin2b catalog models
2 Grin2b lines with QC documentation and technical support. Grin2b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Grin2b mouse model?
We have 2 Grin2b models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Grin2b Mouse Model Types
A Grin2b knockout mouse has the Grin2b gene permanently inactivated, enabling loss of function studies. A Grin2b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Grin2b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Grin2b organized by modification type. Each URL is indexable and matches common search patterns.