Conventional / global / constitutive KO
●3 Models Available
Grin2c Conditional Knockout, Knockout mouse models
Browse 3 Grin2c mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Grin2c conditional knockout mouse, Grin2c knockout mouse. Contact us for availability and fast turnaround.
Why model Grin2c
Grin2c, the mouse ortholog of human GRIN2C, encodes GluN2C, an NMDA receptor subunit whose expression is concentrated in cerebellar granule cells, thalamic relay nuclei, oligodendrocyte lineage cells, and some astrocytes, appearing after the second postnatal week. GluN2C-containing receptors are biophysically distinctive: low open probability, weak magnesium block relative to GluN2A and GluN2B, low single-channel conductance, and slow deactivation, which lets them pass current near resting potential and act as tonic rather than coincidence-detecting conductances. Nulls are viable with mild cerebellar motor learning deficits, so conditional alleles serve cell-type attribution in thalamocortical or glial compartments rather than lethality rescue. Because GluN2A and GluN2B dominate most forebrain synapses and can populate triheteromeric receptors with GluN2C, interpret loss-of-function data with subunit-resolved pharmacology. Positive allosteric modulators selective for GluN2C and GluN2D have species-divergent sites, making humanized ligand-binding or amino-terminal domain knockins the right choice for translational pharmacology endpoints.
What Grin2c mouse models are available?
ingenious targeting laboratory offers 3 distinct Grin2c (GRIN2C) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Grin2c model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Grin2c allele types
Knockout, conditional, knockin, humanized, and related paths for Grin2c (human GRIN2C). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Grin2c catalog models
3 Grin2c lines with QC documentation and technical support. Grin2c floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Grin2c mouse model?
We have 3 Grin2c models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Grin2c Mouse Model Types
A Grin2c knockout mouse has the Grin2c gene permanently inactivated, enabling loss of function studies. A Grin2c conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Grin2c, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Grin2c organized by modification type. Each URL is indexable and matches common search patterns.