Conventional / global / constitutive KO
●3 Models Available
Notch1 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Notch1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Notch1 conditional knockout mouse, Notch1 knockin mouse, Notch1 knockout mouse. Request a quote within 24 hours.
Why model Notch1
Notch1, the mouse ortholog of human NOTCH1, encodes a single-pass receptor whose EGF-like repeats 11 and 12 bind Dll and Jag ligands, with Fringe-mediated O-fucose elongation tuning ligand preference; furin cleavage at S1 generates a heterodimer held together by the negative regulatory region, and mechanical pulling by an endocytosing ligand exposes S2 for Adam10, after which gamma-secretase cleaves at S3 to release the intracellular domain, which enters the nucleus, displaces corepressors from Rbpj, and recruits Maml to activate Hes and Myc, until a carboxy-terminal PEST degron directs Fbxw7-dependent turnover. Human T-cell leukemia mutations cluster in the negative regulatory region and PEST, while loss underlies Adams-Oliver syndrome and bicuspid aortic valve. Homozygous nulls die near E10.5 with somitogenesis and vascular defects, so conditional alleles are standard, and Lox-Stop-Lox intracellular domain knockins, patient-matched PEST truncations, and humanized negative regulatory regions for antibody testing answer separate questions. Notch2 partially compensates, so plan compound genetics.
What Notch1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Notch1 (NOTCH1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Notch1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Notch1 allele types
Knockout, conditional, knockin, humanized, and related paths for Notch1 (human NOTCH1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Notch1 catalog models
3 Notch1 lines with QC documentation and technical support. Notch1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Notch1 (NOTCH1) from ITL supported projects.
- Small GTPase RhoE/Rnd3 is a critical regulator of Notch1 signaling.Zhu Z, Todorova K, Lee KK, Wang J, Kwon E, Kehayov I, Kim HG, Kolev V, Dotto GP, Lee SW, Mandinova A. (2014). Cancer Res 74: 2082-2093
Looking for a Notch1 mouse model?
We have 3 Notch1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Notch1 Mouse Model Types
A Notch1 knockout mouse has the Notch1 gene permanently inactivated, enabling loss of function studies. A Notch1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Notch1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Notch1 knockin models carry a precisely inserted sequence at the Notch1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Notch1 organized by modification type. Each URL is indexable and matches common search patterns.