Conventional / global / constitutive KO
●2 Models Available
Notch4 Conditional Knockout, Knockout mouse models
Browse 2 Notch4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Notch4 conditional knockout mouse, Notch4 knockout mouse. Contact us for availability and fast turnaround.
Why model Notch4
Encoding the most divergent family member, Notch4 is the mouse ortholog of human NOTCH4 and produces a receptor with markedly fewer EGF repeats, endothelium-restricted expression, and weaker transactivation than Notch1, still relying on Adam and gamma-secretase processing to liberate an intracellular domain that engages Rbpj and Maml. The locus is historically important as int3, where MMTV proviral insertion truncates the extracellular region and yields a constitutively active intracellular fragment that drives mammary tumors, which established that ligand-independent Notch signaling is transforming. Homozygous nulls are viable and fertile with normal vasculature, and combining them with Notch1 deficiency does not markedly worsen the Notch1 phenotype, so loss-of-function alleles at this locus are of limited value on their own. The productive designs are therefore gain-of-function: endothelial-restricted intracellular domain expression to test arteriovenous malformation and tumor angiogenesis phenotypes, paired with a validated Cdh5-CreER driver so activation timing is controlled rather than constitutive.
What Notch4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Notch4 (NOTCH4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Notch4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Notch4 allele types
Knockout, conditional, knockin, humanized, and related paths for Notch4 (human NOTCH4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Notch4 catalog models
2 Notch4 lines with QC documentation and technical support. Notch4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Notch4 mouse model?
We have 2 Notch4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Notch4 Mouse Model Types
A Notch4 knockout mouse has the Notch4 gene permanently inactivated, enabling loss of function studies. A Notch4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Notch4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Notch4 organized by modification type. Each URL is indexable and matches common search patterns.