Conventional / global / constitutive KO
●2 Models Available
Notch2 Conditional Knockout, Knockout mouse models
Browse 2 Notch2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Notch2 conditional knockout mouse, Notch2 knockout mouse. Request a quote within 24 hours.
Why model Notch2
Ligand-dependent proteolysis governs Notch2, the mouse ortholog of human NOTCH2, which encodes a receptor with the same modular architecture as Notch1, using EGF repeats for Dll and Jag engagement, a negative regulatory region stabilized by S1 furin processing, sequential Adam10 and gamma-secretase cleavage, and an intracellular domain that partners with Rbpj and Maml before PEST-directed degradation. Its human genetics run in both directions: haploinsufficiency and hypomorphic alleles cause Alagille syndrome with bile duct paucity, whereas PEST-truncating mutations that stabilize the intracellular domain cause Hajdu-Cheney syndrome with acro-osteolysis, and NOTCH2 lesions recur in marginal zone lymphoma. Homozygous nulls die in mid-gestation, while the hypomorphic allele survives with cardiac, renal, and hepatic defects, so conditional deletion is the standard route for biliary, splenic, and skeletal studies. A PEST truncation knockin models gain-of-function bone disease, and receptor-specific humanization supports paralog-selective antibodies. Notch1 overlaps in liver and B cell compartments, making Notch1 and Notch2 compound alleles necessary for full penetrance.
What Notch2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Notch2 (NOTCH2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Notch2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Notch2 allele types
Knockout, conditional, knockin, humanized, and related paths for Notch2 (human NOTCH2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Notch2 catalog models
2 Notch2 lines with QC documentation and technical support. Notch2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Notch2 (NOTCH2) from ITL supported projects.
- ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.Gibb DR, El Shikh M, Kang DJ, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG, Dempsey PJ, Crawford HC, Conrad DH. (2010). J Exp Med207: 623-635
Looking for a Notch2 mouse model?
We have 2 Notch2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Notch2 Mouse Model Types
A Notch2 knockout mouse has the Notch2 gene permanently inactivated, enabling loss of function studies. A Notch2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Notch2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Notch2 organized by modification type. Each URL is indexable and matches common search patterns.