Conventional / global / constitutive KO
●4 Models Available
Notch3 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Notch3 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Notch3 conditional knockout mouse, Notch3 knockin mouse, Notch3 knockout mouse. Request a quote within 24 hours.
Why model Notch3
Notch3, the mouse ortholog of human NOTCH3, encodes a receptor with a shorter extracellular region than Notch1 and expression concentrated in vascular smooth muscle and pericytes, where canonical Adam10 and gamma-secretase processing releases an intracellular domain that acts through Rbpj and Maml to drive Heyl and mural cell maturation. Its disease logic is distinctive and not simple loss of function: CADASIL arises from cysteine-altering substitutions within EGF repeats that promote ectodomain multimerization and granular osmiophilic material deposition in arteriolar walls, a proteinopathy mechanism, whereas PEST-truncating alleles that stabilize signaling cause lateral meningocele syndrome. Homozygous nulls are viable with immature, poorly differentiated arterial smooth muscle and impaired myogenic responses, so germline alleles are usable, but the informative CADASIL model requires a patient-matched cysteine substitution knockin, ideally in a humanized EGF repeat context, rather than deletion. Notch1 contributes to mural cell biology, so compound alleles and a smooth muscle driver refine interpretation.
What Notch3 mouse models are available?
ingenious targeting laboratory offers 4 distinct Notch3 (NOTCH3) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Notch3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Notch3 allele types
Knockout, conditional, knockin, humanized, and related paths for Notch3 (human NOTCH3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Notch3 catalog models
4 Notch3 lines with QC documentation and technical support. Notch3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Notch3 mouse model?
We have 4 Notch3 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Notch3 Mouse Model Types
A Notch3 knockout mouse has the Notch3 gene permanently inactivated, enabling loss of function studies. A Notch3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Notch3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Notch3 knockin models carry a precisely inserted sequence at the Notch3 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Notch3 organized by modification type. Each URL is indexable and matches common search patterns.