Conventional / global / constitutive KO
●2 Models Available
Dlg1 Conditional Knockout, Knockout mouse models
Browse 2 Dlg1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Dlg1 conditional knockout mouse, Dlg1 knockout mouse. Contact us for availability and fast turnaround.
Why model Dlg1
Dlg1, ortholog of human DLG1, encodes SAP97, a membrane-associated guanylate kinase built from three PDZ domains, an SH3 module and a catalytically inactive guanylate kinase domain, whose alternatively spliced N-terminal L27 or palmitoylated variants determine whether it acts in epithelial polarity with Scribble and Lgl or in neuronal receptor trafficking. In neurons it escorts GluA1 through the secretory pathway and binds Kv1.4 and the cardiac sodium channel Nav1.5, linking it to both synaptic delivery and excitability, while in epithelia it enforces basolateral identity and is a target of viral oncoproteins. Constitutive nulls die perinatally with cleft palate, urogenital and kidney defects, so a conditional null is mandatory for adult neural work; pair Camk2a-Cre for forebrain synapses or a cardiomyocyte driver for conduction endpoints. Dlg2, Dlg3 and Dlg4 share domain architecture and partially substitute at the postsynaptic density, so compound alleles and direct receptor surface measurements are advisable.
What Dlg1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Dlg1 (DLG1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dlg1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dlg1 allele types
Knockout, conditional, knockin, humanized, and related paths for Dlg1 (human DLG1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dlg1 catalog models
2 Dlg1 lines with QC documentation and technical support. Dlg1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Dlg1 mouse model?
We have 2 Dlg1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dlg1 Mouse Model Types
A Dlg1 knockout mouse has the Dlg1 gene permanently inactivated, enabling loss of function studies. A Dlg1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dlg1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Dlg1 organized by modification type. Each URL is indexable and matches common search patterns.