Conventional / global / constitutive KO
●2 Models Available
Dlg4 Conditional Knockout, Knockout mouse models
Browse 2 Dlg4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Dlg4 conditional knockout mouse, Dlg4 knockout mouse. Contact us for availability and fast turnaround.
Why model Dlg4
PSD-95, encoded by Dlg4 as the ortholog of human DLG4, is the dominant scaffold of the excitatory postsynaptic density, anchored by palmitoylation of Cys3 and Cys5 and organizing receptors through PDZ1 and PDZ2 binding to the GluN2 ESDV motif and to transmembrane AMPA receptor regulatory protein C-termini including γ-8, while PDZ2 recruits nNOS and the guanylate kinase domain assembles the GKAP, Shank and Homer layers. Its abundance sets AMPA receptor content per synapse, and disruption of the nNOS interaction is an established stroke neuroprotection strategy. Constitutive nulls are viable but show markedly enhanced long-term potentiation, absent long-term depression and impaired spatial learning, so lethality is not a constraint; a conditional null with Camk2a-Cre isolates forebrain contributions and a palmitoylation-site or PDZ-binding knockin separates membrane anchoring from protein interaction. Because Dlg1, Dlg2 and Dlg3 upregulate and partly substitute, compound conditional genetics and quantitative postsynaptic density proteomics should be planned from the start.
What Dlg4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Dlg4 (PSD-95) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Dlg4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Dlg4 allele types
Knockout, conditional, knockin, humanized, and related paths for Dlg4 (human DLG4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Dlg4 catalog models
2 Dlg4 lines with QC documentation and technical support. Dlg4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Dlg4 mouse model?
We have 2 Dlg4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Dlg4 Mouse Model Types
A Dlg4 knockout mouse has the Dlg4 gene permanently inactivated, enabling loss of function studies. A Dlg4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dlg4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Dlg4 organized by modification type. Each URL is indexable and matches common search patterns.