Conventional / global / constitutive KO
●2 Models Available
Foxo1 Conditional Knockout, Knockout mouse models
Browse 2 Foxo1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Foxo1 conditional knockout mouse, Foxo1 knockout mouse. Request a quote within 24 hours.
Why model Foxo1
Foxo1, the mouse ortholog of human FOXO1, encodes a forkhead box O transcription factor that binds the DAF-16 family consensus element through a winged helix domain and activates gluconeogenic, autophagy, cell cycle arrest and stress resistance programs including G6pc, Pck1, Cdkn1b, Gadd45a and Sod2. Insulin and growth factor signaling suppress it directly, since AKT phosphorylates threonine 24, serine 253 and serine 316 to create 14-3-3 binding sites that drive nuclear exclusion and SKP2 dependent degradation, while SIRT1 deacetylation and JNK phosphorylation reverse that control under stress. PAX3-FOXO1 and PAX7-FOXO1 fusions from the t(2;13) and t(1;13) translocations define alveolar rhabdomyosarcoma, a distinct oncogenic use of this locus. Null embryos die at midgestation from vascular remodeling failure, so conditional alleles are required, and a triple alanine knockin that resists AKT phosphorylation gives constitutive nuclear activity for insulin resistance studies. Foxo3 and Foxo4 compensate substantially, so compound conditional alleles are needed for hematopoietic and metabolic endpoints.
What Foxo1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Foxo1 (FOXO1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Foxo1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Foxo1 allele types
Knockout, conditional, knockin, humanized, and related paths for Foxo1 (human FOXO1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Foxo1 catalog models
2 Foxo1 lines with QC documentation and technical support. Foxo1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Foxo1 mouse model?
We have 2 Foxo1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Foxo1 Mouse Model Types
A Foxo1 knockout mouse has the Foxo1 gene permanently inactivated, enabling loss of function studies. A Foxo1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Foxo1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Foxo1 organized by modification type. Each URL is indexable and matches common search patterns.