Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM · DEVELOPING · IN PRODUCTION
Grin2d Conditional Knockout, Knockout mouse models
Browse 3 Grin2d mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Grin2d conditional knockout mouse, Grin2d knockout mouse. Request a quote within 24 hours.
Why model Grin2d
Encoding GluN2D, Grin2d is the mouse ortholog of human GRIN2D and produces the NMDA receptor subunit with the slowest deactivation kinetics of the family, generating currents that decay over seconds and remain relatively resistant to magnesium block, properties that suit its enrichment in GABAergic interneurons, subthalamic nucleus, substantia nigra, and midbrain circuits. Expression peaks embryonically and in early postnatal life, then persists in defined inhibitory populations, where GluN2D-containing triheteromers shape sustained depolarization rather than brief coincidence detection. De novo GRIN2D variants such as V667I cause severe developmental and epileptic encephalopathy through gain of function, prolonging current and increasing agonist potency, so knockin alleles model the disease far better than deletion, which yields viable mice with modest behavioral change. Grin2c overlaps functionally in some populations and GluN2A or GluN2B substitutes elsewhere, so combine subunit-resolved recordings with interneuron-restricted Cre drivers and reserve humanized alleles for GluN2D-preferring modulator testing.
What Grin2d mouse models are available?
ingenious targeting laboratory offers 3 distinct Grin2d (GRIN2D) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Grin2d model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Grin2d allele types
Knockout, conditional, knockin, humanized, and related paths for Grin2d (human GRIN2D). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Grin2d catalog models
3 Grin2d lines with QC documentation and technical support. Grin2d floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Grin2d-Flox
CKOCKO
These mice carry loxP sites flanking exon 7-8 of Grin2d gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Grin2d gene.
In production — inquireCKO 260382 - Order
Grin2d-KO(2)
KOKO
The exon 7-8 of Grin2d gene was deleted to generate Grin2d knockout mouse.
In DevelopmentKO 263810 - Order
Grin2d-KO
KOKO
Exon 2 of Grin2d gene was deleted to generate Grin2d knockout mice.
Sperm CryopreservedKO 200846
Looking for a Grin2d mouse model?
We have 3 Grin2d models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Grin2d Mouse Model Types
A Grin2d knockout mouse has the Grin2d gene permanently inactivated, enabling loss of function studies. A Grin2d conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Grin2d, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Grin2d organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Grin2d line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.