Conventional / global / constitutive KO
●8 Models Available
READY TO SHIP!
LIVE · SPERM · EMBRYO · DEVELOPING
Il10 Conditional Knockout, Knockin, Knockout mouse models
Browse 8 Il10 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il10 conditional knockout mouse, Il10 knockin mouse, Il10 knockout mouse. Request a quote within 24 hours.
Why model Il10
Il10 corresponds to human IL10 and encodes a class 2 alpha-helical cytokine that signals as a homodimer through IL10RA paired with the shared IL10RB chain, activating JAK1 and STAT3 to induce SOCS3, suppress MHC class II and costimulation, and shut down interleukin 12 and TNF production in activated macrophages. Because that program enforces mucosal tolerance, germline Il10 nulls develop spontaneous microbiota dependent colitis whose severity tracks with housing and Helicobacter status, mirroring human infantile inflammatory bowel disease caused by IL10, IL10RA, and IL10RB mutations. That biology forces careful design: a conditional null with Foxp3-Cre, Cd19-Cre, or Lyz2-Cre attributes suppression to a defined source, whereas germline loss only demonstrates that the axis exists. Humanization supports testing of engineered interleukin 10 agonists and receptor blocking antibodies whose species selectivity is absolute. Interpretation demands controlled microbiota and littermate comparisons, since cage effects can exceed genotype effects when colitis onset is the readout.
What Il10 mouse models are available?
ingenious targeting laboratory offers 8 distinct Il10 (IL10) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 8 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il10 allele types
Knockout, conditional, knockin, humanized, and related paths for Il10 (human IL10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il10 catalog models
8 Il10 lines with QC documentation and technical support. Il10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Il10-Flox(2)
CKOCKO
These mice carry loxP sites flanking exon1 of Il10 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il10 gene.While Il10-Flox mice(Stock No.KO 18001）have been pulled from shelves for some reasons.
Embryo CryopreservedCKO 200003 - Order
Il10-IRES-mCherry
KIOther
The IRES-mCherry expression cassette was knocked into the Il10 gene stop codon site.
In DevelopmentKI 263595 - Order
Il10-2A-tdTomato
KIFluorescent Model
The 2A-tdTomato expression cassette was knocked into the Il10 gene stop codon site.
Sperm CryopreservedKI 232238 - Order
Il10-HiBiT
KIOther Toolbox (non-Cre, non-Fluorescent)
HiBiT was knocked into the stop coden of Il10 gene via CRISPR/Cas9 mediated recombination.
Embryo CryopreservedKI 200328 - Order
Il10-mCherry
KIOther
The Kozak-mCherry-WPRE-pA expression cassette was knocked into the Il10 gene start codon site.
In DevelopmentKI 263596 - Order
Il10-2A-DTR-2A-mCherry
KIFluorescent Model, Other Toolbox (non-Cre, non-Fluorescent)
The P2A-DTR-T2A-mCherry expression cassette was knocked into the Il10 gene stop codon site.
Sperm CryopreservedKI 242161 - Order
Il10-KO
KOKO, Disease Model
This Il10 knockout strain is established by crossing Il10-CKO and Dppa3-Cre mice strains together. The Il10 flox mice possess loxP sites flanking exons 1 .
LiveKO 190426 - Order
Il10-KO(BALB/c)
KOKO, Disease Model
Exon 1-5 of Il10 gene was deleted to generate Il10 knockout mice.
LiveKO 200637
Looking for a Il10 mouse model?
We have 8 Il10 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model8
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il10 Mouse Model Types
A Il10 knockout mouse has the Il10 gene permanently inactivated, enabling loss of function studies. A Il10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il10 knockin models carry a precisely inserted sequence at the Il10 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il10 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Il10 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.