Conventional / global / constitutive KO
●5 Models Available
Il12a Conditional Knockout, Knockin, Knockout mouse models
Browse 5 Il12a mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il12a conditional knockout mouse, Il12a knockin mouse, Il12a knockout mouse. Request a quote within 24 hours.
Why model Il12a
Il12a, the mouse ortholog of human IL12A, encodes the p35 subunit, and its central design trap is subunit sharing: p35 heterodimerizes with p40 from Il12b to form bioactive interleukin 12, and with EBI3 to form interleukin 35, an inhibitory cytokine of regulatory T and B cells. Interleukin 12 acts through IL-12Rbeta1 and IL-12Rbeta2 to trigger JAK2 and STAT4, imprinting Th1 commitment and interferon gamma production, while interleukin 35 signals through gp130 with IL-12Rbeta2 to activate STAT1 and STAT4 in a suppressive configuration. A germline Il12a null therefore removes a proinflammatory and an anti-inflammatory cytokine simultaneously, so phenotypes read as net effects rather than clean interleukin 12 loss. Dissection requires triangulation across Il12b, Ebi3, and Il12rb2 alleles, plus conditional Il12a deletion with dendritic cell or B cell restricted Cre drivers, and humanization when the endpoint is ustekinumab-class or p35 directed antibody pharmacology.
What Il12a mouse models are available?
ingenious targeting laboratory offers 5 distinct Il12a (IL12A) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il12a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il12a allele types
Knockout, conditional, knockin, humanized, and related paths for Il12a (human IL12A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il12a catalog models
5 Il12a lines with QC documentation and technical support. Il12a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Il12a-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 2108334 - Order
Il12a-2A-tdTomato
Knockinfluorescent mouse
In production — inquireKI 253278 - Order
Il12a-Luc-2A-EGFP
Knockinfluorescent mouse
embryo cryopreservationKI 00024 - Order
Il12a-KO(2)
KnockoutKO/CKO mice
sperm cryopreservationKO 226097 - Order
Il12a-KO
KnockoutKO/CKO mice
sperm cryopreservationKO 190454
Looking for a Il12a mouse model?
We have 5 Il12a models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il12a Mouse Model Types
A Il12a knockout mouse has the Il12a gene permanently inactivated, enabling loss of function studies. A Il12a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il12a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il12a knockin models carry a precisely inserted sequence at the Il12a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il12a organized by modification type. Each URL is indexable and matches common search patterns.