Conventional / global / constitutive KO
●4 Models Available
Il1a Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Il1a mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Il1a conditional knockout mouse, Il1a knockin mouse, Il1a knockout mouse. Request a quote within 24 hours.
Why model Il1a
Il1a, mouse ortholog of human IL1A, encodes interleukin 1 alpha, a cytokine whose full-length precursor is already bioactive, carries a nuclear localization sequence, tethers to the plasma membrane, and is released as an alarmin when cells die by necrosis or necroptosis, with calpain dependent processing enhancing potency. This makes its regulation fundamentally different from interleukin 1 beta, which requires inflammasome caspase-1 cleavage, even though both signal through IL-1R1 with IL1RAP to recruit MyD88, IRAK4, and IRAK1 and activate NF-kB and p38. Interleukin 1 alpha therefore dominates sterile injury, ultraviolet damage, and tumor associated inflammation, and its nuclear pool contributes transcriptionally in ways a secretion-focused readout misses. Distinguish these functions with a conditional null, a nuclear localization deficient or membrane-anchored knockin, and humanization for bermekimab-class antibodies. Because Il1b and Il1rn act on the same receptor, compound alleles or Il1r1 deletion are needed to bound total interleukin 1 activity in any model.
What Il1a mouse models are available?
ingenious targeting laboratory offers 4 distinct Il1a (IL1A) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Il1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Il1a allele types
Knockout, conditional, knockin, humanized, and related paths for Il1a (human IL1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Il1a catalog models
4 Il1a lines with QC documentation and technical support. Il1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Il1a mouse model?
We have 4 Il1a models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Il1a Mouse Model Types
A Il1a knockout mouse has the Il1a gene permanently inactivated, enabling loss of function studies. A Il1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Il1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Il1a knockin models carry a precisely inserted sequence at the Il1a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Il1a organized by modification type. Each URL is indexable and matches common search patterns.