Conventional / global / constitutive KO
●2 Models Available
Pdk4 Conditional Knockout, Knockout mouse models
Browse 2 Pdk4 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pdk4 conditional knockout mouse, Pdk4 knockout mouse. Request a quote within 24 hours.
Why model Pdk4
As the mouse ortholog of human PDK4, Pdk4 encodes the pyruvate dehydrogenase kinase isoform whose control is overwhelmingly transcriptional, induced by fasting, glucocorticoids, PPAR alpha and PPAR delta, FOXO1 and estrogen-related receptors, and repressed by insulin, so its abundance tracks nutrient state rather than acute allosteric input. By phosphorylating E1 alpha during starvation, high fat feeding or diabetes, it conserves pyruvate and lactate for gluconeogenesis while forcing muscle and heart onto fatty acid oxidation, and sustained induction contributes to the metabolic inflexibility seen in insulin resistance and heart failure. That regulatory logic favors a floxed conditional null with muscle, cardiac or hepatic Cre drivers to localize where induction drives glucose oxidation suppression, and a humanized allele where inhibitor pharmacology is the goal. Overlap with Pdk1, Pdk2 and Pdk3 is genuine, so compound conditionals prevent misreading a buffered phenotype. Align the allele with clamp studies, substrate tracing or cardiac efficiency endpoints.
What Pdk4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Pdk4 (PDK4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdk4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdk4 allele types
Knockout, conditional, knockin, humanized, and related paths for Pdk4 (human PDK4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Pdk4 mouse model?
We have 2 Pdk4 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdk4 Mouse Model Types
A Pdk4 knockout mouse has the Pdk4 gene permanently inactivated, enabling loss of function studies. A Pdk4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdk4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pdk4 organized by modification type. Each URL is indexable and matches common search patterns.