Conventional / global / constitutive KO
●2 Models Available
Pdk3 Conditional Knockout, Knockout mouse models
Browse 2 Pdk3 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pdk3 conditional knockout mouse, Pdk3 knockout mouse. Request a quote within 24 hours.
Why model Pdk3
Pdk3, the mouse ortholog of human PDK3, encodes the pyruvate dehydrogenase kinase isoform with the highest intrinsic specific activity toward E1 alpha and the strongest dependence on binding the lipoyl-bearing L2 domain of the E2 core for full activation, a property that renders it comparatively resistant to feedback inhibition by pyruvate. That biochemistry carries clinical weight, since the gene is X-linked and gain-of-function missense variants strengthening L2 binding cause X-linked Charcot-Marie-Tooth neuropathy type 6 through chronic PDH hyperphosphorylation and suppressed oxidative flux. The design fork is therefore unusual for this family: a hyperactivating patient-matched knockin, not a null, reproduces the human disease, while a conditional null answers the separate question of where this isoform normally restrains PDH. Because Pdk1, Pdk2 and Pdk4 overlap substantially, a single knockout is easily buffered and compound alleles should be planned. Match allele to endpoint, pairing peripheral nerve analysis with the knockin and flux measurements with the null.
What Pdk3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Pdk3 (PDK3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdk3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdk3 allele types
Knockout, conditional, knockin, humanized, and related paths for Pdk3 (human PDK3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdk3 catalog models
2 Pdk3 lines with QC documentation and technical support. Pdk3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pdk3 mouse model?
We have 2 Pdk3 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdk3 Mouse Model Types
A Pdk3 knockout mouse has the Pdk3 gene permanently inactivated, enabling loss of function studies. A Pdk3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdk3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pdk3 organized by modification type. Each URL is indexable and matches common search patterns.