Conventional / global / constitutive KO
●3 Models Available
Tgfb2 Conditional Knockout, Knockout mouse models
Browse 3 Tgfb2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tgfb2 conditional knockout mouse, Tgfb2 knockout mouse. Contact us for availability and fast turnaround.
Why model Tgfb2
Among the three ligand isoforms, Tgfb2, the mouse ortholog of human TGFB2, has the lowest intrinsic affinity for TGFBR2 and therefore depends on the coreceptor betaglycan to present ligand efficiently for ALK5 recruitment and SMAD2 and SMAD3 phosphorylation, a biochemical distinction that predicts why its in vivo requirements barely overlap with Tgfb1. Nulls die perinatally with cardiac outflow tract and aortic arch malformation, craniofacial and eye defects, and inner ear anomalies, while human heterozygous loss of function causes Loeys-Dietz syndrome type 4 with thoracic aortic aneurysm, and elevated aqueous humor ligand features in glaucoma. Consequently, neural crest and endothelial conditional nulls using Wnt1-Cre or Tie2-Cre isolate lineage requirements, haploinsufficient and patient missense knockins reproduce the aneurysm paradox in which reduced ligand yields increased downstream signaling, and humanization enables isoform-selective antibody testing. Tgfb1 and Tgfb3 share receptors yet compensate only partially, so isoform-specific alleles remain necessary rather than interchangeable.
What Tgfb2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tgfb2 (TGFB2) catalog mouse models in the TGF-beta/Activin/Nodal family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tgfb2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tgfb2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tgfb2 (human TGFB2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tgfb2 catalog models
3 Tgfb2 lines with QC documentation and technical support. Tgfb2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tgfb2 mouse model?
We have 3 Tgfb2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tgfb2 Mouse Model Types
A Tgfb2 knockout mouse has the Tgfb2 gene permanently inactivated, enabling loss of function studies. A Tgfb2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tgfb2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tgfb2 organized by modification type. Each URL is indexable and matches common search patterns.