Conventional / global / constitutive KO
●3 Models Available
Tgfbr2 Conditional Knockout, Knockout mouse models
Browse 3 Tgfbr2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tgfbr2 conditional knockout mouse, Tgfbr2 knockout mouse. Request a quote within 24 hours.
Why model Tgfbr2
Tgfbr2, the mouse ortholog of human TGFBR2, encodes the constitutively active type II serine/threonine kinase receptor that captures TGFB1, TGFB2, and TGFB3 and transphosphorylates the GS domain of the type I receptor ALK5 (Tgfbr1), licensing phosphorylation of the SMAD2 and SMAD3 carboxy-terminal SSXS motifs and SMAD4-dependent nuclear transcription. Human disease logic splits cleanly: biallelic frameshifts in the polyadenine BAT-RII tract drive microsatellite-unstable carcinomas, whereas heterozygous kinase-domain missense alleles cause Loeys-Dietz syndrome with paradoxically elevated SMAD2 output in aortic wall. Straight germline deletion is lethal near E10.5 from failed yolk sac vasculogenesis and hematopoiesis, so epithelial, fibroblast, or T cell questions require a floxed kinase-domain allele driven by a validated lineage Cre. Because ligand redundancy across three TGFB isoforms and intact activin and BMP arms (Acvr2a, Acvr2b, Bmpr2) preserve parallel SMAD1/5/8 flux, receptor deletion silences only the SMAD2/3 branch; reserve epitope humanization for ligand trap and antibody pharmacology.
What Tgfbr2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tgfbr2 (TGFBR2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tgfbr2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tgfbr2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tgfbr2 (human TGFBR2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tgfbr2 catalog models
3 Tgfbr2 lines with QC documentation and technical support. Tgfbr2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tgfbr2 mouse model?
We have 3 Tgfbr2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tgfbr2 Mouse Model Types
A Tgfbr2 knockout mouse has the Tgfbr2 gene permanently inactivated, enabling loss of function studies. A Tgfbr2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tgfbr2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tgfbr2 organized by modification type. Each URL is indexable and matches common search patterns.