Conventional / global / constitutive KO
●2 Models Available
Tgfb3 Conditional Knockout, Knockout mouse models
Browse 2 Tgfb3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tgfb3 conditional knockout mouse, Tgfb3 knockout mouse. Contact us for availability and fast turnaround.
Why model Tgfb3
Tgfb3 is the mouse ortholog of human TGFB3 and encodes the isoform with the highest intrinsic affinity for TGFBR2, capable of forming heterodimers with TGFB1 and concentrated in the medial edge epithelium of the fusing palatal shelves, where it drives the SMAD2 and SMAD3 program required for epithelial seam breakdown. Nulls develop cleft palate with an essentially normal craniofacial skeleton plus delayed lung maturation, a strikingly restricted phenotype, and human variants cause Loeys-Dietz syndrome type 5 and arrhythmogenic right ventricular cardiomyopathy type 1, while the isoform has long been pursued for scarless wound repair. Epithelial conditional deletion using K14-Cre separates palatal seam requirements from mesenchymal signaling, patient knockins address aortic and myocardial disease mechanism, and humanization supports isoform-selective pharmacology. Although Tgfb1 and Tgfb2 use the same receptor pair, their nonoverlapping null phenotypes show compensation is limited in vivo, so treat isoform identity as functionally meaningful.
What Tgfb3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Tgfb3 (TGFB3) catalog mouse models in the TGF-beta/Activin/Nodal family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tgfb3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tgfb3 allele types
Knockout, conditional, knockin, humanized, and related paths for Tgfb3 (human TGFB3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tgfb3 catalog models
2 Tgfb3 lines with QC documentation and technical support. Tgfb3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tgfb3 mouse model?
We have 2 Tgfb3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tgfb3 Mouse Model Types
A Tgfb3 knockout mouse has the Tgfb3 gene permanently inactivated, enabling loss of function studies. A Tgfb3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tgfb3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tgfb3 organized by modification type. Each URL is indexable and matches common search patterns.