Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · SPERM · DEVELOPING
Tgfbr1 Conditional Knockout, Knockout, Xenograft-Applicable mouse models
Browse 3 Tgfbr1 mouse models including conditional knockout, knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tgfbr1 conditional knockout mouse, Tgfbr1 knockout mouse, Tgfbr1 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Tgfbr1
Tgfbr1 encodes ALK5, ortholog of human TGFBR1, a type I serine and threonine kinase receptor recruited into a heterotetramer by ligand-bound TGFBR2, which transphosphorylates the glycine and serine rich GS box; FKBP12 occupies that box in the basal state to prevent leaky activation, and once released the kinase phosphorylates SMAD2 and SMAD3 at their carboxy-terminal motifs while also engaging TRAF6, TAK1 and p38 for non-SMAD output. Heterozygous kinase domain mutations cause Loeys-Dietz syndrome with aortic aneurysm, so patient knockins address vascular biology that deletion does not. Germline deletion is embryonic lethal from yolk sac vasculogenesis failure, mandating conditional nulls for fibrosis, immune tolerance and tumor microenvironment studies, while a constitutively active T204D knockin driven from a lox-stop-lox cassette tests sufficiency. Because ALK1 and ALK2 transduce distinct ligand subsets, do not assume ALK5 loss removes all superfamily input from a tissue.
What Tgfbr1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tgfbr1 (TGFBR1) catalog mouse models, featuring conditional knockout, standard knockout, and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Tgfbr1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tgfbr1 allele types
Knockout, conditional, knockin, humanized, and related paths for Tgfbr1 (human TGFBR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tgfbr1 catalog models
3 Tgfbr1 lines with QC documentation and technical support. Tgfbr1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tgfbr1-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 3 of Tgfbr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tgfbr1 gene.
Sperm CryopreservedCKO 200142 - Order
Tgfbr1-KO
KOKO
Exon 3 of Tgfbr1 gene was deleted to generate Tgfbr1 knockout mice. Lethal phenotypes associated with this genetic modification have been reported. For details, please refer to the MGI ID in the gene information.
LiveKO 225082 - Order
Tgfbr1-Flox/Cdh5-2A-CreERT2
XACKO, Cre/Dre Toolbox
The Tgfbr1-Flox (CKO 200142) was crossed with Cdh5-2A-CreERT2(KI 200173) to generate Tgfbr1-Flox/Cdh5-2A-CreERT2 mice.
In DevelopmentXA 261471
Looking for a Tgfbr1 mouse model?
We have 3 Tgfbr1 models in stock — including Conditional Knockout, Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tgfbr1 Mouse Model Types
A Tgfbr1 knockout mouse has the Tgfbr1 gene permanently inactivated, enabling loss of function studies. A Tgfbr1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tgfbr1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tgfbr1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tgfbr1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.