Conventional / global / constitutive KO
●2 Models Available
Tgfbr1 Conditional Knockout, Knockout mouse models
Browse 2 Tgfbr1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tgfbr1 conditional knockout mouse, Tgfbr1 knockout mouse. Request a quote within 24 hours.
Why model Tgfbr1
Tgfbr1 encodes ALK5, ortholog of human TGFBR1, a type I serine and threonine kinase receptor recruited into a heterotetramer by ligand-bound TGFBR2, which transphosphorylates the glycine and serine rich GS box; FKBP12 occupies that box in the basal state to prevent leaky activation, and once released the kinase phosphorylates SMAD2 and SMAD3 at their carboxy-terminal motifs while also engaging TRAF6, TAK1 and p38 for non-SMAD output. Heterozygous kinase domain mutations cause Loeys-Dietz syndrome with aortic aneurysm, so patient knockins address vascular biology that deletion does not. Germline deletion is embryonic lethal from yolk sac vasculogenesis failure, mandating conditional nulls for fibrosis, immune tolerance and tumor microenvironment studies, while a constitutively active T204D knockin driven from a lox-stop-lox cassette tests sufficiency. Because ALK1 and ALK2 transduce distinct ligand subsets, do not assume ALK5 loss removes all superfamily input from a tissue.
What Tgfbr1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Tgfbr1 (TGFBR1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tgfbr1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tgfbr1 allele types
Knockout, conditional, knockin, humanized, and related paths for Tgfbr1 (human TGFBR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tgfbr1 catalog models
2 Tgfbr1 lines with QC documentation and technical support. Tgfbr1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tgfbr1 mouse model?
We have 2 Tgfbr1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tgfbr1 Mouse Model Types
A Tgfbr1 knockout mouse has the Tgfbr1 gene permanently inactivated, enabling loss of function studies. A Tgfbr1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tgfbr1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tgfbr1 organized by modification type. Each URL is indexable and matches common search patterns.