Conventional / global / constitutive KO
●3 Models Available
Smad3 Conditional Knockout, Knockout mouse models
Browse 3 Smad3 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Smad3 conditional knockout mouse, Smad3 knockout mouse. Request a quote within 24 hours.
Why model Smad3
Lacking the exon 3 insert that keeps SMAD2 off DNA, the protein encoded by Smad3 (human SMAD3) binds CAGAC SMAD-binding elements directly through its MH1 domain after ALK5 phosphorylates its carboxy-terminal SSVS motif, then trimerizes with SMAD4 and cooperates with AP-1, TCF and FOXO factors to drive collagen, Serpine1 and Foxp3 transcription. This direct DNA engagement makes it the dominant effector for TGF beta driven fibrosis, epithelial to mesenchymal transition and induced regulatory T cell generation. Human loss-of-function mutations cause aneurysm-osteoarthritis syndrome, a Loeys-Dietz variant, providing a knockin rationale distinct from deletion. Constitutive nulls are viable with immune dysregulation, colorectal tumors and protection from experimental fibrosis, so conditional alleles are needed chiefly to separate stromal, epithelial and T cell compartments. Given that Smad2 and Smad3 diverge in DNA binding rather than receptor use, allele selection should follow whether the endpoint is transcriptional output or receptor-proximal signaling.
What Smad3 mouse models are available?
ingenious targeting laboratory offers 3 distinct Smad3 (SMAD3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Smad3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Smad3 allele types
Knockout, conditional, knockin, humanized, and related paths for Smad3 (human SMAD3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Smad3 catalog models
3 Smad3 lines with QC documentation and technical support. Smad3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Smad3 mouse model?
We have 3 Smad3 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Smad3 Mouse Model Types
A Smad3 knockout mouse has the Smad3 gene permanently inactivated, enabling loss of function studies. A Smad3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Smad3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Smad3 organized by modification type. Each URL is indexable and matches common search patterns.