Conventional / global / constitutive KO
●1 Model Available
Smad2 Conditional Knockout mouse model
Browse 1 Smad2 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Smad2
Smad2, ortholog of human SMAD2, encodes a receptor-regulated SMAD for the TGF beta, activin and Nodal branch, phosphorylated on its carboxy-terminal SSMS motif by the type I receptors ALK4, ALK5 and ALK7 and then partnered with SMAD4. Its distinguishing feature is exon 3, a thirty-residue insert in the MH1 domain that blocks direct DNA contact, so the full-length protein acts through partners such as FOXH1, whereas the naturally occurring exon 3 deleted isoform binds SMAD-binding elements much like SMAD3. Germline deletion is early embryonic lethal with failure of egg cylinder patterning and mesoderm formation, mandating conditional nulls for adult fibrosis, immune or tumor endpoints. Exon 3 deletion knockins and carboxy-terminal phospho-dead alleles separate DNA binding mode from receptor input. Because Smad3 shares receptor input and SMAD4 partnership while binding DNA directly, phenotypes attributed to Smad2 should be tested against compound Smad2 and Smad3 genetics.
What Smad2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Smad2 (SMAD2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Smad2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Smad2 allele types
Knockout, conditional, knockin, humanized, and related paths for Smad2 (human SMAD2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Smad2 catalog models
1 Smad2 line with QC documentation and technical support. Smad2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Smad2-Flox
Conditional KnockoutKO/CKO mice
embryo cryopreservationCKO 200220
Looking for a Smad2 mouse model?
We have 1 Smad2 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Smad2 Mouse Model Types
A Smad2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Smad2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Smad2 organized by modification type. Each URL is indexable and matches common search patterns.