Conventional / global / constitutive KO
●2 Models Available
Smad4 Conditional Knockout, Xenograft-Applicable mouse models
Browse 2 Smad4 mouse models including conditional knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Smad4 conditional knockout mouse, Smad4 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Smad4
Every branch of the TGF beta superfamily converges on Smad4 (ortholog of human SMAD4), the sole common mediator SMAD, which trimerizes through its MH2 domain with two receptor-phosphorylated SMADs, either SMAD2 and SMAD3 downstream of TGF beta and activin or SMAD1, SMAD5 and SMAD9 downstream of BMP, and supplies nuclear export control plus the transcriptional activation surface for the complex. Because it is shared, deletion collapses both branches at once, which is informative for tumor suppression but confounds branch attribution. Germline loss is early embryonic lethal at gastrulation, and somatic inactivation defines juvenile polyposis and is a canonical event in pancreatic ductal adenocarcinoma, where conditional nulls combined with Kras G12D and Trp53 alleles reproduce the human progression sequence. When the question is branch-specific, receptor-SMAD conditional alleles are preferable to Smad4 deletion, and MH2 interface knockins test complex assembly without abolishing protein expression.
What Smad4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Smad4 (SMAD4) catalog mouse models, featuring conditional knockout and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Smad4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Smad4 allele types
Knockout, conditional, knockin, humanized, and related paths for Smad4 (human SMAD4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Smad4 catalog models
2 Smad4 lines with QC documentation and technical support. Smad4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Smad4 mouse model?
We have 2 Smad4 models in stock — including Conditional Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Smad4 Mouse Model Types
A Smad4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Smad4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Smad4 organized by modification type. Each URL is indexable and matches common search patterns.