Conventional / global / constitutive KO
●2 Models Available
Smad1 Conditional Knockout, Knockout mouse models
Browse 2 Smad1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Smad1 conditional knockout mouse, Smad1 knockout mouse. Contact us for availability and fast turnaround.
Why model Smad1
Bone morphogenetic protein signaling is transduced by Smad1, the mouse ortholog of SMAD1, a receptor-regulated SMAD whose MH1 domain binds GC-rich BMP response elements and whose MH2 domain is phosphorylated at a carboxy-terminal SSVS motif by the type I receptors ALK1, ALK2, ALK3 and ALK6, after which it trimerizes with SMAD4 and enters the nucleus. Signal duration is set in the linker region, where CDK8 and CDK9 prime and GSK3 extends phosphorylation to recruit the ubiquitin ligase SMURF1, terminating output. Germline deletion is embryonic lethal from allantois and chorioallantoic fusion failure, so conditional nulls with endothelial, chondrocyte or germ cell drivers are required for postnatal questions, and linker phospho-dead knockins uniquely test signal duration. Smad5 and Smad9 are genuinely redundant BMP effectors, so compound conditional alleles are usually necessary before concluding that a BMP-dependent process is Smad1 dependent.
What Smad1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Smad1 (SMAD1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Smad1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Smad1 allele types
Knockout, conditional, knockin, humanized, and related paths for Smad1 (human SMAD1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Smad1 catalog models
2 Smad1 lines with QC documentation and technical support. Smad1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Smad1 mouse model?
We have 2 Smad1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Smad1 Mouse Model Types
A Smad1 knockout mouse has the Smad1 gene permanently inactivated, enabling loss of function studies. A Smad1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Smad1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Smad1 organized by modification type. Each URL is indexable and matches common search patterns.