Conventional / global / constitutive KO
●2 Models Available
Bmp1 Conditional Knockout, Knockout mouse models
Browse 2 Bmp1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bmp1 conditional knockout mouse, Bmp1 knockout mouse. Contact us for availability and fast turnaround.
Why model Bmp1
Despite its name, Bmp1, the mouse ortholog of human BMP1, encodes no SMAD-activating ligand but rather a secreted zinc-dependent astacin family metalloprotease with CUB and EGF domains that functions as procollagen C-proteinase, removing the C-terminal propeptides of procollagen I, II, and III to permit fibril assembly. The same catalytic activity matures prolysyl oxidase for crosslinking and cleaves chordin, thereby liberating BMP2 and BMP4 for receptor engagement, placing this protease simultaneously in matrix assembly and morphogen availability. Human biallelic mutations cause osteogenesis imperfecta type XIII with high bone mass fractures and dentinogenesis defects. Constitutive nulls die perinatally with a persistent ventral body wall closure defect, so conditional floxed alleles driven by Col1a1-Cre or Prrx1-Cre are the correct tool for adult bone and fibrosis endpoints. Critically, the tolloid paralogs Tll1 and Tll2 share substrate specificity and mask single-locus loss, so compound conditional genetics should be planned before interpreting matrix phenotypes.
What Bmp1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bmp1 (BMP1) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bmp1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bmp1 allele types
Knockout, conditional, knockin, humanized, and related paths for Bmp1 (human BMP1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bmp1 catalog models
2 Bmp1 lines with QC documentation and technical support. Bmp1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bmp1 mouse model?
We have 2 Bmp1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bmp1 Mouse Model Types
A Bmp1 knockout mouse has the Bmp1 gene permanently inactivated, enabling loss of function studies. A Bmp1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bmp1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bmp1 organized by modification type. Each URL is indexable and matches common search patterns.