Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · IN PRODUCTION
Bmp15 Conditional Knockout, Knockout mouse models
Browse 2 Bmp15 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Bmp15 conditional knockout mouse, Bmp15 knockout mouse. Request a quote within 24 hours.
Why model Bmp15
Oocyte-restricted expression distinguishes Bmp15, the mouse ortholog of human BMP15, whose product is a TGF-beta superfamily ligand secreted by growing oocytes, largely as a covalent heterodimer with GDF9 known as cumulin. That heterodimer signals to adjacent granulosa cells through BMPR1B and BMPR2 with SMAD1, SMAD5, and SMAD8 phosphorylation, coordinating cumulus expansion, glycolytic support of the oocyte, and suppression of premature luteinization. Human heterozygous variants cause primary ovarian insufficiency, and ovine FecX alleles produce dose-dependent hyperprolificacy then sterility, illustrating a steep genotype to ovulation-rate relationship. Mouse nulls are viable with only modest subfertility, so a simple knockout is a weak model; instead, patient-specific missense knockins that impair proprotein processing or heterodimer formation better recapitulate human disease logic. Because Gdf9 partners with and partially covers this ligand, compound or allelic-series designs are advisable. Humanized knockins are the right platform for recombinant cumulin or in vitro maturation reagent testing against defined ovulation endpoints.
What Bmp15 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bmp15 (BMP15) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bmp15 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bmp15 allele types
Knockout, conditional, knockin, humanized, and related paths for Bmp15 (human BMP15). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bmp15 catalog models
2 Bmp15 lines with QC documentation and technical support. Bmp15 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Bmp15-Flox
CKOCKO
These mice carry loxP sites flanking exon2 of Bmp15 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmp15 gene.
In production — inquireCKO 260813 - Order
Bmp15-KO
KOKO
The exon 2 of Bmp15 gene was deleted to generate Bmp15 knockout mouse.
LiveKO 240454
Looking for a Bmp15 mouse model?
We have 2 Bmp15 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bmp15 Mouse Model Types
A Bmp15 knockout mouse has the Bmp15 gene permanently inactivated, enabling loss of function studies. A Bmp15 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bmp15, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bmp15 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Bmp15 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.