Conventional / global / constitutive KO
●2 Models Available
Bmp10 Conditional Knockout, Knockout mouse models
Browse 2 Bmp10 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bmp10 conditional knockout mouse, Bmp10 knockout mouse. Contact us for availability and fast turnaround.
Why model Bmp10
Bmp10, ortholog of human BMP10, encodes a BMP9-related ligand whose expression in the embryonic ventricular trabeculae and the adult right atrium makes it the most anatomically restricted member of the family. Processed dimers, including circulating BMP9 and BMP10 heterodimers, bind the type I receptor ALK1 with BMPR2 or ACVR2A and the endothelial coreceptor endoglin to phosphorylate SMAD1, SMAD5, and SMAD8, enforcing vascular quiescence and driving cardiomyocyte proliferation through Nkx2-5 and Mef2c. Germline nulls die near midgestation with hypoplastic trabeculae and arrested cardiac growth, so cardiac and endothelial conditional floxed alleles are required for any postnatal vascular malformation or pulmonary hypertension study. Loss-of-function logic here connects directly to hereditary hemorrhagic telangiectasia, where ALK1 and endoglin lesions phenocopy ligand deprivation. Because BMP9 encoded by Gdf2 substitutes substantially in circulation, compound Gdf2 and Bmp10 genetics is necessary to unmask ALK1 pathway collapse, and ligand-trap or antibody testing benefits from epitope-matched humanization.
What Bmp10 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bmp10 (BMP10) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bmp10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bmp10 allele types
Knockout, conditional, knockin, humanized, and related paths for Bmp10 (human BMP10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bmp10 catalog models
2 Bmp10 lines with QC documentation and technical support. Bmp10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bmp10 mouse model?
We have 2 Bmp10 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bmp10 Mouse Model Types
A Bmp10 knockout mouse has the Bmp10 gene permanently inactivated, enabling loss of function studies. A Bmp10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bmp10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bmp10 organized by modification type. Each URL is indexable and matches common search patterns.