Conventional / global / constitutive KO
●2 Models Available
Bmp5 Conditional Knockout, Knockout mouse models
Browse 2 Bmp5 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bmp5 conditional knockout mouse, Bmp5 knockout mouse. Contact us for availability and fast turnaround.
Why model Bmp5
Bmp5, mouse ortholog of human BMP5, encodes a BMP6 and BMP7 subgroup ligand that signals via ALK2, ALK3, or ALK6 with BMPR2 into SMAD1, SMAD5, and SMAD8, and it is best known through the classical short ear mutation, a naturally occurring allelic series affecting external ear cartilage, sternebrae, vertebral processes, ribs, and lung septation. Because those spontaneous alleles range from regulatory deletions to protein nulls, the locus is an unusually clean example of enhancer-specific versus coding disruption yielding distinct anatomical subsets, which is an argument for enhancer-targeted deletions rather than whole-gene ablation when a specific skeletal element is the readout. Homozygous nulls are viable and fertile, so constitutive knockouts are tractable for cartilage, fracture repair, and dendrite arborization studies. Substantial redundancy with Bmp6 and Bmp7 in kidney, bone, and iron-related contexts means single-locus loss is often silent outside the short ear domains. Match compound conditionals to whichever endpoint, skeletal patterning or repair, is being scored.
What Bmp5 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bmp5 (BMP5) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bmp5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bmp5 allele types
Knockout, conditional, knockin, humanized, and related paths for Bmp5 (human BMP5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bmp5 catalog models
2 Bmp5 lines with QC documentation and technical support. Bmp5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bmp5 mouse model?
We have 2 Bmp5 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bmp5 Mouse Model Types
A Bmp5 knockout mouse has the Bmp5 gene permanently inactivated, enabling loss of function studies. A Bmp5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bmp5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bmp5 organized by modification type. Each URL is indexable and matches common search patterns.