Conventional / global / constitutive KO
●2 Models Available
Bmp2 Conditional Knockout, Knockout mouse models
Browse 2 Bmp2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bmp2 conditional knockout mouse, Bmp2 knockout mouse. Contact us for availability and fast turnaround.
Why model Bmp2
Bmp2, mouse ortholog of human BMP2, encodes a proteolytically processed homodimeric ligand that engages BMPR1A or BMPR1B with BMPR2 to phosphorylate SMAD1, SMAD5, and SMAD8, which complex with SMAD4 to activate Id1, Runx2, and Sp7 while also feeding noncanonical TAK1 and p38 output. It is the classical osteoinductive ligand of the family, driving mesenchymal condensation, chondrogenesis, and osteoblast commitment, and its recombinant human form is used clinically for spinal fusion where ectopic bone is a recognized liability. Germline deletion is embryonic lethal with amnion and chorion failure plus malpositioned hearts, so conditional floxed alleles with Prrx1-Cre, Col2a1-Cre, or Sp7-Cre are mandatory for skeletal work, and inducible overexpression or degradation-resistant knockins model heterotopic ossification. Extracellular antagonists noggin, gremlin, and chordin and the closely related ligand BMP4 buffer local loss, making compound Bmp2 and Bmp4 conditionals the honest design when the endpoint is complete osteogenic signaling collapse.
What Bmp2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bmp2 (BMP2) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bmp2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bmp2 allele types
Knockout, conditional, knockin, humanized, and related paths for Bmp2 (human BMP2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bmp2 catalog models
2 Bmp2 lines with QC documentation and technical support. Bmp2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bmp2 mouse model?
We have 2 Bmp2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bmp2 Mouse Model Types
A Bmp2 knockout mouse has the Bmp2 gene permanently inactivated, enabling loss of function studies. A Bmp2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bmp2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bmp2 organized by modification type. Each URL is indexable and matches common search patterns.