What Bmp3 Knockout mouse models are available?

When Bmp3 Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Bmp3 knockout embryonic lethal in mice?

It depends on background and allele design. Some Bmp3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Bmp3 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Bmp3?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●2 Models Available

Bmp3 Knockout mouse models

Name: Bmp3-KO(2)
Brand: ingenious targeting laboratory
SKU: KO 231435
Availability: PreOrder

Browse 2 Bmp3 mouse models including knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.

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Why model Bmp3

Functionally inverted relative to its osteogenic relatives, Bmp3, the mouse ortholog of human BMP3 and historically called osteogenin, encodes an abundant bone matrix ligand that antagonizes bone formation by signaling through ACVR2B with ALK4 to phosphorylate SMAD2 and SMAD3, thereby competing with SMAD1, SMAD5, and SMAD8 output from BMP2, BMP4, and BMP7 and restraining osteoprogenitor commitment. Deletion in mice is viable and produces increased trabecular bone volume, establishing the gene as a negative regulator whose loss is an anabolic gain, while transgenic overexpression yields spontaneous rib fractures and reduced bone mass. That directionality dictates allele choice: constitutive nulls address bone accrual and fracture healing, conditional floxed alleles separate osteocyte-derived from marrow stromal ligand, and overexpression knockins model the osteopenic extreme. Its closest paralog Gdf10, also named BMP3B, shares SMAD2 and SMAD3 bias and can obscure single-locus effects in skeletal readouts. Align allele class with microCT, dynamic histomorphometry, or callus bridging endpoints accordingly.

What Bmp3 mouse models are available?

ingenious targeting laboratory offers 2 distinct Bmp3 (BMP3) catalog mouse models in the BMP/GDF family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
2 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

Bmp3 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
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Humanized
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Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Bmp3 allele types

Knockout, conditional, knockin, humanized, and related paths for Bmp3 (human BMP3). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

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Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Bmp3 catalog models

2 Bmp3 lines with QC documentation and technical support.

Bmp3-KO
Knockout
KO/CKO mice
liveKO 190529
Order
Bmp3-KO(2)
Knockout
KO/CKO mice
sperm cryopreservationKO 231435
Order

Looking for a Bmp3 mouse model?

We have 2 Bmp3 models in stock — including Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation