Conventional / global / constitutive KO
●1 Model Available
Smarcb1 Conditional Knockout mouse model
Browse 1 Smarcb1 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Smarcb1
Loss of Smarcb1, the mouse ortholog of human SMARCB1 (SNF5, INI1, BAF47), removes a core non-catalytic subunit of the BAF chromatin remodeling complex that stabilizes the ATPase module on nucleosomes and directs residual complexes toward typical enhancers, so its absence redistributes SMARCA4 to super-enhancers and creates a striking dependence on PRC2 and EZH2 activity. Biallelic inactivation, frequently 22q11 deletion plus a truncating hit, defines rhabdoid tumor of kidney, atypical teratoid rhabdoid tumor, epithelioid sarcoma, and renal medullary carcinoma, and germline heterozygosity produces rhabdoid tumor predisposition syndrome, making this one of the most genomically simple pediatric cancers. Homozygous germline deletion is lethal shortly after implantation, whereas conditional nulls yield rhabdoid or lymphoid tumors with very short latency, itself a practical design constraint. No paralog compensates, unlike the SMARCA4 and SMARCA2 pair, so single-locus conditional deletion is interpretable; select inducible Cre timing and lineage to control histology and EZH2 inhibitor endpoints.
What Smarcb1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Smarcb1 (SMARCB1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Smarcb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Smarcb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Smarcb1 (human SMARCB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Smarcb1 catalog models
1 Smarcb1 line with QC documentation and technical support. Smarcb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Smarcb1-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 190042
Looking for a Smarcb1 mouse model?
We have 1 Smarcb1 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Smarcb1 Mouse Model Types
A Smarcb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Smarcb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Smarcb1 organized by modification type. Each URL is indexable and matches common search patterns.