Conventional / global / constitutive KO
●4 Models Available
Tlr3 Conditional Knockout, Knockout mouse models
Browse 4 Tlr3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tlr3 conditional knockout mouse, Tlr3 knockout mouse. Contact us for availability and fast turnaround.
Why model Tlr3
Tlr3, the mouse ortholog of human TLR3, encodes the endosomal receptor for double-stranded RNA, binding duplexes of roughly forty five base pairs or longer across two sites on the lateral face of its leucine-rich repeat ectodomain so that two receptors are bridged into a signaling dimer, with acidic pH and UNC93B1-dependent trafficking required for function. Uniquely among Toll-like receptors it signals exclusively through TRIF rather than MyD88, recruiting TRAF3, TBK1, and IKK epsilon to phosphorylate IRF3 for type I interferon and, through RIPK1, driving NF-kB or RHIM-dependent death, and human TLR3 deficiency predisposes specifically to herpes simplex encephalitis. Nulls are viable and immunocompetent outside particular viral challenges, so germline deletion is practical, while conditional alleles resolve neuronal, epithelial, and dendritic cell sensing and humanized ectodomains matter for agonist pharmacology. Since Ddx58 and Ifih1 also sense duplex RNA in cytosol, plan compound genetics around interferon induction or neurotropic infection endpoints.
What Tlr3 mouse models are available?
ingenious targeting laboratory offers 4 distinct Tlr3 (TLR3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tlr3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr3 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr3 (human TLR3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr3 catalog models
4 Tlr3 lines with QC documentation and technical support. Tlr3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tlr3 mouse model?
We have 4 Tlr3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr3 Mouse Model Types
A Tlr3 knockout mouse has the Tlr3 gene permanently inactivated, enabling loss of function studies. A Tlr3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tlr3 organized by modification type. Each URL is indexable and matches common search patterns.