Conventional / global / constitutive KO
●4 Models Available
Tlr5 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Tlr5 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tlr5 conditional knockout mouse, Tlr5 knockin mouse, Tlr5 knockout mouse. Request a quote within 24 hours.
Why model Tlr5
Serving as the flagellin sensor, Tlr5 is the mouse ortholog of human TLR5 and encodes a cell-surface leucine-rich repeat receptor that recognizes the conserved D1 domain of bacterial flagellin through a lateral surface centered on repeats seven to ten, an interface that also mediates receptor dimerization and subsequent MyD88, IRAK4, and TRAF6 dependent NF-kB activation. Because this epitope is buried in assembled filaments, TLR5 detects monomeric flagellin released by motile bacteria, and signaling in intestinal epithelium and lamina propria dendritic cells controls flagellin-specific IgA, antimicrobial peptide expression, and microbiota composition, with human dominant-negative variants linked to Legionella susceptibility. Nulls are viable but develop altered microbiota, metabolic syndrome features on some backgrounds, and impaired mucosal antibody responses, so germline deletion is informative provided cohousing and microbiome controls are used, while conditional alleles resolve epithelial versus dendritic cell sensing. Align allele choice with colonization, adjuvant, or metabolic endpoints.
What Tlr5 mouse models are available?
ingenious targeting laboratory offers 4 distinct Tlr5 (TLR5) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tlr5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr5 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr5 (human TLR5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr5 catalog models
4 Tlr5 lines with QC documentation and technical support. Tlr5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tlr5 mouse model?
We have 4 Tlr5 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr5 Mouse Model Types
A Tlr5 knockout mouse has the Tlr5 gene permanently inactivated, enabling loss of function studies. A Tlr5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Tlr5 knockin models carry a precisely inserted sequence at the Tlr5 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Tlr5 organized by modification type. Each URL is indexable and matches common search patterns.