Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM · INJECTION IN PROGRESS
Tlr7 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Tlr7 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Tlr7 conditional knockout mouse, Tlr7 knockin mouse, Tlr7 knockout mouse. Contact us for availability and fast turnaround.
Why model Tlr7
Tlr7 is the mouse ortholog of human TLR7 and encodes an endosomal receptor that requires UNC93B1 for trafficking and proteolytic maturation, then senses single-stranded RNA degradation products through two cooperating sites, one binding guanosine or synthetic agonists such as imiquimod and R848 and a second binding short uridine-containing oligoribonucleotides, with dimerization driving MyD88, IRAK4, and IRF7 dependent type I interferon in plasmacytoid dendritic cells. Dosage is central to disease logic: the Yaa locus duplication of Tlr7 accelerates murine lupus, human gain of function substitutions such as Y264H that increase guanosine affinity cause childhood systemic lupus erythematosus, and escape from X inactivation raises expression in females. Design accordingly, using conditional nulls to assign requirement to plasmacytoid dendritic cells or B cells, copy-number or point-mutant knockins for gain of function, and humanized alleles for agonist pharmacology. Tlr8 and Tlr9 overlap in nucleic acid sensing, so target autoantibody, interferon signature, or adjuvant endpoints.
What Tlr7 mouse models are available?
ingenious targeting laboratory offers 4 distinct Tlr7 (TLR7) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tlr7 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tlr7 allele types
Knockout, conditional, knockin, humanized, and related paths for Tlr7 (human TLR7). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tlr7 catalog models
4 Tlr7 lines with QC documentation and technical support. Tlr7 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tlr7-Flox
CKOCKO
These strains carry loxP sites flanking exon 3 of Tlr7 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tlr7 gene.
Sperm CryopreservedCKO 231882 - Order
Tlr7-Y264H
KIPoint Mutation
These mice carry a Y264Hamino acids mutation of Tlr7 gene.
Sperm CryopreservedKI 230071 - Order
Tlr7-KO(BALB/c)
KOKO
Exon 3 of Tlr7 gene was deleted to generate Tlr7 knockout mice.
Injection in ProgressKO 200646 - Order
Tlr7-KO
KOKO
This Tlr7 knockout mouse model was generated by knocking out the exon 3 region of the Tlr7 .
Sperm CryopreservedKO 190166
Looking for a Tlr7 mouse model?
We have 4 Tlr7 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tlr7 Mouse Model Types
A Tlr7 knockout mouse has the Tlr7 gene permanently inactivated, enabling loss of function studies. A Tlr7 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tlr7, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Tlr7 knockin models carry a precisely inserted sequence at the Tlr7 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Tlr7 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tlr7 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.